Influence of the Light Schedule on the Toxic Interaction between Propranolol and Disopyramide in Chick Embryos
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概要
- 論文の詳細を見る
The effect of the light schedule on toxic interactions between propranolol and disopyramide were studied in chick embryos. Fertilized eggs of White Leghorns were incubated under dark conditions and investigated, on two occasions, under light conditions or under dark conditions. Propranolol, with and without disopyramide, was injected into the air sac of fertilized eggs on the 16th day of incubation. Electrocardiograms(ECGs) were recorded 0 to 60 min after the injection. After in injection of propranolol with disopyramide, the heart rate was significantly decreased compared with the injection of propranolol alone under light conditions. In addition, this toxic interaction between propranolol and disopyramide was more severe under dark conditions than under light conditions. These findings indicate that manipulation of the light schedule has a marked influence on the toxic interaction between propranolol and disopyramide in chick embryos.
- 公益社団法人日本薬学会の論文
- 2001-04-01
著者
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SUGIYAMA Takashi
Division of Pathophysiology, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceu
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YOSHIYAMA Yuji
Division of Clinical Pharmacy, Kyoritsu University of Pharmacy
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KANKE Motoko
Division of Clinical Pharmacy, Kyoritsu University of Pharmacy
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Sugiyama T
Division Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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TSUCHIMOTO Kanji
Division of Pathophysiology, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceu
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KANKE Matoko
Division of Clinical Pharmacy, Kyoritsu College of Pharmacy
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Kanke Motoko
Division Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Yoshiyama Y
Division Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Yoshiyama Yuji
Division Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Sugiyama T
Department Of Electrical And Electronic Engineering Tokyo Institute Of Technology
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Tsuchimoto Kanji
Division Of Pathophysiology Center For Clinical Pharmacy And Clinical Sciences School Of Pharmaceuti
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Sugiyama Takashi
Division Of Pathophysiology Center For Clinical Pharmacy And Clinical Sciences School Of Pharmaceuti
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Sugiyama Takashi
Division of Clinical Pharmacy, Kyoritsu University of Pharmacy
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