Cardiotoxicity of Trastuzumab (Herceptin) in Chick Embryos
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概要
- 論文の詳細を見る
The cardiac toxicity of trastuzumab was studied in chick embryos. Fertilized eggs of White Leghorns were incubated and investigated. Trastuzumab 5 mg/egg (low dose) or 15 mg/egg (high dose) was injected into the air sac of a fertilized egg on the 16th day of incubation. Electrocardiograms (ECGs) were recorded 0 to 60 min after the injection. After low dosing of trastuzumab, the heart rate was not different compared with the control. However, the heart rate was significantly decreased by high dosing of trastuzumab. In addition, arrhythmia was produced by high dosing of trastuzumab. These findings indicate that trastuzumab has a marked dose- and time-dependent influence on the heart rate in chick embryos.
- 公益社団法人日本薬学会の論文
- 2003-06-01
著者
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SUGIYAMA Takashi
Division of Pathophysiology, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceu
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YOSHIYAMA Yuji
Division of Clinical Pharmacy, Kyoritsu University of Pharmacy
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KANKE Motoko
Division of Clinical Pharmacy, Kyoritsu University of Pharmacy
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Sugiyama T
Division Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Kanke Motoko
Division Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Yoshiyama Y
Division Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Yoshiyama Yuji
Division Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Sugiyama T
Department Of Electrical And Electronic Engineering Tokyo Institute Of Technology
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Sugiyama Takashi
Division Of Pathophysiology Center For Clinical Pharmacy And Clinical Sciences School Of Pharmaceuti
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Sugiyama Takashi
Division of Clinical Pharmacy, Kyoritsu University of Pharmacy
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