Protective Effect of Ceftriaxone against the Nephrotoxicity of Isepamicin Administered Once Daily in Rats
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概要
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The protective effect of ceftriaxone on isepamicin-induced nephorotoxicity was investigated. For 14d, Wistar rats were administered either ceftriaxone 100 mg/kg intraperitoneally, isepamicin 300 mg/kg subcutaneously, or ceftriaxone isepamicin in combination. The animals given 300 mg/kg of isepamicin showed a significant increase in urine NAG (N-acetyl-β-D-glucosaminidase) levels as compared with the control animals which received saline (p<0.01). However, the increase in NAG level was markedly less when isepamicin was administered in combination with ceftriaxone (p<0.01). Ceftriaxone alone had no effect on urine NAG activity. Serum creatinine levels were significantly higher in animals treated with isepamicin alone than in control animals (p<0.01) or animals receiving the isepamicin ceftriaxone combination (p<0.01). After 14 d of treatment, ceftriaxone had not accumulated in renal tissue, but it did reduce the renal intracortical accumulation of isepamicin (p<0.01). Histopathologically, ceftriaxone induced very few cellular alterations and considerably reduced the manifestation of typical signs of isepamicin nephrotoxicity. This investigation demonstrates that ceftriaxone protects animals against isepamicin-induced nephrotoxicity.
- 公益社団法人日本薬学会の論文
- 1998-05-15
著者
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KANKE Motoko
Division of Clinical Pharmacy, Kyoritsu University of Pharmacy
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YAZAKI Tomoko
Division of Clinical Pharmacy, Kyoritsu College of Pharmacy
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Kanke Motoko
Division Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Yoshiyama Y
Division Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Yazaki Tomoko
Division Of Clinical Pharmacy Kyoritsu College Of Pharmacy
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Yoshiyama Yuji
Division Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Beauchamp Denis
Research Center For Infectious Diseases Laval University
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