Drug-Drug Interactions between Antiarrhythmic Drugs in Chick Embryos(Pharmacology)
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概要
- 論文の詳細を見る
The drug-drug interactions between antiarrhythmic drugs were studied in chick embryos. Fertilized eggs of White Leghorns were incubated and investigated. Procainamide or flecainide with and without propranolol was injected into the air sac of a fertilized egg. Electrocardiograms (ECGs) were recorded 0 to 60 min after the injection. After each drug injection alone, the heart rate was not different compared with the control. However, the heart rate was significantly decreased by combinations of procainamide and propranolol or flecainide and propranolol. In addition, arrhythmia was produced in combination with propranolol. These findings indicate that the drug-drug interactions between antiarrhythmic drugs have a marked influence on the heart rate in chick embryos.
- 公益社団法人日本薬学会の論文
- 2004-01-01
著者
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SUGIYAMA Takashi
Division of Pathophysiology, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceu
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YOSHIYAMA Yuji
Division of Clinical Pharmacy, Kyoritsu University of Pharmacy
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KANKE Motoko
Division of Clinical Pharmacy, Kyoritsu University of Pharmacy
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Sugiyama T
Division Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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TSUCHIMOTO Kanji
Division of Pathophysiology, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceu
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Kanke Motoko
Division Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Yoshiyama Y
Division Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Yoshiyama Yuji
Division Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Sugiyama T
Department Of Electrical And Electronic Engineering Tokyo Institute Of Technology
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Tsuchimoto Kanji
Division Of Pathophysiology Center For Clinical Pharmacy And Clinical Sciences School Of Pharmaceuti
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Sugiyama Takashi
Division Of Pathophysiology Center For Clinical Pharmacy And Clinical Sciences School Of Pharmaceuti
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Sugiyama Takashi
Division of Clinical Pharmacy, Kyoritsu University of Pharmacy
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