Antimicrobial Activity of Acrinol and Pyoktanin against Methicillin-resistant Staphylococcus aureus

概要

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Nasal carriage of methicillin-resistant Staphylococcus aureus (MRSA) can serve as a significant source of MRSA infection in patients. Ethacridine (acrinol. ACR) and methylrosanilium chloride (pyoktanin, PYO) present antimicrobial activity against gram-positive bacteria and therefore are clinically used as topical disinfectants. The purpose of the present study was to evaluate the in vitro antimicrobial activity of ACR and PYO against MRSA, in order to ascertain whether or not ointments of ACR and PYO are applicable to the eliminatation of MRSA from the anterior nares. Minimal inhibitory concentrations (MICs) of ACR and PYO for 100% of MRSA isolates were 400 μg/ml and 0.5 μg/ml, respectively. Clinical isolates of MRSA were killed within 10 min at 20℃ after exposure to 1% ACR, 0.01% PYO and 0.1% PYO, while no bactericidal effect of O. 1% ACR was observed after 24-h exposure. The logarithmic reduction factors of 0.01% and 0.1% PYO for an MRSA isolate after 60-min exposure at 30℃ were over 4. All of the 0.01% PYO ointments prepared with three different bases showed antimicrobial activities against the MRSA isolate tested. The MIC_<100> of PYO ointment prepared with hydrophilic plastibase for MRSA was 100 μg/g. These results suggest that PYO oitment is applicable for topical use to eradicate nasal carriage of MRSA.
日本医療薬学会の論文
1994-06-20