Comparison of Saliva Stimulation Methods for Noninvasive Therapeutic Drug Monitoring by Using Saliva Samples

概要

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To find out an appropriate therapeutic drug monitoring method by using saliva, we investigated the effect of four kinds of saliva stimulation methods on salivary pH, flow rate and composition in normal male subjects. Each of methods showed significantly different pH, flow rate and compositions (total protein, K^+ and creatinine levels). It was observed that the simplest method (i.e. to move mouth and tongue) had the smallest inter-individual variation of pH and relatively small inter-individual variations of total protein and Na^+ levels. In addition, this method showed no diurnal variations of pH, flow rate and compositions (total protein, Na^+ and K^+ levels). The present results suggest that to move mouth and tongue for salivation may be the simplest and most suitable stimulation method for therapeutic drug monitoring by using saliva samples. Furthermore, this method was found to be well applicable to a pilot study on the saliva to serum concentration ratio of mexiletine hydrochloride after the oral administration in normal subject.
日本医療薬学会の論文
1989-12-20