ROLE OF MANDIBULAR STRIATED DUCT IN SALIVARY EXCRETION OF UREA IN DOGS
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概要
- 論文の詳細を見る
The role of mandibular striated duct in salivary excretion of endogenous urea was studied by a technique of retrograde ductal injection of HgCl_2 and a stop flow analysis. (1) It was verified in this study that treatment with HgCl_2 markedly inhibited Na^+ reabsorption in the striated duct so that water reabsorption driven by the Na^+ reabsorption would be inhibited substantially. (2) The saliva/plasma concentration ratios (S/P ratios) of urea in HgCl_2-treated saliva (about 0.71) were significantly higher than those in untreated saliva (about 0.37). (3) The excretion rate of urea in HgCl_2-treated saliva (about 0.02 mg/min/kg) was also significantly higher than those in untreated saliva (about 0.01 mg/min/kg) despite the same flow rate for both saliva samples. Furthermore, (4) The S/P ratios of urea in the second (0.25 - 0.50 ml) poststop-flow saliva (about 0.65) were significantly higher than those in prestop-flow saliva (about 0.35). These results suggest a possibility that salivary urea is reabsorbed in the dog mandibular striated duct and that the enhancement of the S/P ratio as well as the salivary level of urea by the pre-treatment with HgCl_2 may be due to the inhibition of urea reabsorption.
- 公益社団法人日本薬学会の論文
著者
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WATANABE Jun
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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OZEKI Shoji
Faculty of Pharmaceutical Sciences, Nagoya City University
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OZEKI Shoji
Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Nagoya City University
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IWAMOTO KIKUO
Department of Pharmacy, Shimane Medical University Hospital
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MIZUNO Satoshi
Department of Bioactive Molecules, National Institute of Health
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Ozeki Shoji
Faculty Of Pharmaceutical Sciences Nagoya City University
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Iwamoto Kikuo
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:(present Ad
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Mizuno Satoshi
アール・ピー・シーラー株式会社学術課
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Mizuno S
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Mizuno Satoshi
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Watanabe J
Department Of Pharmaceutics College Of Pharmacy Nihon University
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Mizuno S
アール・ピー・シーラー株式会社学術課
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Watanabe Jun
Department Of Anatomy & Cell Science Kansai Medical University
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