In Situ Jejunal Absorption of [6]-Gingerol in Rats

概要

論文の詳細を見る
We investigated the in situ jejunal absorption of [6]-gingerol to determine the extent of its intestinal absorption after administering the drug solution (2 mg in 0.9% NaCl solution containing 5% Tween 80) into the closed jejunal loop in rats. The plasma concentration of [6]-gingerol in the mesenteric venous blood was measured periodically up to 60 min, and the drug levels in mucosal and muscular tissues were also determined at the end of the absorption experiments. In addition, the remaining amount of [6]-gingerol in the loop was determined. Initially, the blood cell-plasma partition of [6]-gingerol was investigated following intravenous administration (3 mg/kg) in rats to calculate the drug levels in whole blood from the plasma levels measured in the absorption experiments. The blood cell-plasma concentration partition ratio (K) for [6]-gingerol after instantaneous equilibrium was achieved was estimated as 0.489. The cumulative percentage of [6]-gingerol absorbed into the mesenteric venous blood by 60 min was estimated to be 10.86±2.61% of the initial dose The recovery of[6]-gingerol was calculated by dividing the sum of the cumulative amount of [6]-gingerol absorbed in the mesenteric blood, the amount of the drug taken up by the jejunal mucosa and muscle at 60 min, and the remaining amount of [6]-gingerol in the closed loop by the initial dose, and was estimated as 58.7±9.2%. The residual 40% of the initial dose was not recovered as[6]-gingerol. These findings suggest that [6]-gingerol is absorbed to a considerable extent from the rat jejunal lumen, and, furthermore, that [6]-gingerol may be metabolized and/or decomposed to a substantial extent in the rat jejunal lumen and/or tissue.
日本医療薬学会の論文
1993-08-20

In Situ Jejunal Absorption of [6]-Gingerol in Rats

スポンサーリンク

概要

著者

関連論文

スポンサーリンク