EFFECTS OF URETHANE ANESTHESIA AND AGE ON ORGAN BLOOD FLOW IN RATS MEASURED BY HYDROGEN GAS CLEARANCE METHOD
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概要
- 論文の詳細を見る
Apparent blood flow rate in jejunum, kidney, liver or skeletal muscle was directly measured by the hydrogen gas clearance method in 7-week-old rats anesthetized with urethane at four dose levels (0.5,0.8,1.0 and 1.5 g/kg, i.p.). The apparent blood flow in each organ or tissue was reduced with the urethane dose. Jejunal blood flow was most sensitive to the dose-related decrease. Assuming that the organ (or tissue) to blood partition coefficient of hydrogen gas is unity and extrapolating the flow data to zero urethane dose for each organ, the flow rate values were almost comparable with the literature data in conscious rats. The applicability of the hydrogen gas clearance method to examine the effect of age on organ or tissue blood flow in rats was also discussed. Organs with relatively high sensitivity to aging were the stomach, jejunum and kidney.
- 公益社団法人日本薬学会の論文
著者
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Iwamoto Kikuo
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:(present Ad
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Iwamoto Kikuo
Department Of Hospital Pharmacy Shimane Medical University:department Of Biopharmaceutics Faculty Of
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Watanabe Jun
Department Of Anatomy & Cell Science Kansai Medical University
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ATSUMI FUMIE
Department of Hospital Pharmacy, Shimane Medical University
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Atsumi Fumie
Department Of Hospital Pharmacy Shimane Medical University:department Of Biopharmaceutics Faculty Of
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Watanabe Jun
Department Of Hospital Pharmacy Shimane Medical University:department Of Biopharmaceutics Faculty Of
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