DISPOSITION OF FRACTIONATED ^3H-HEPARIN IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
To evaluate the disposition of fractionated ^3H-heparin, high affinity fraction (fraction A) and low affinity fraction (fraction NA) to protamine were prepared in this study from commercial ^3H-heparin by affinity chromatography on protamine-Sepharose and gel filtration chromatography. Following intravenous administration of fraction A to rats, it seemed that the radioactivity in plasma declined one-exponentially with time to a pseudo-steady-state level, and 20.5% of dose was excreted in urine in 5 h. However, following the administration of fraction NA to rats, the plasma radioactivity curve was different from that of fraction A, and 69.8% of dose was excreted in urine in 5 h. It was found that fraction A and fraction NA had the distinctly different disposition characteristics in the body. Additionally, whole-body autoradiography with fraction A showed that the liver, bone marrow, kidney cortex, salivary gland and intestine played an important role in the distribution of it. It was suggested by gel filtration chromatography and affinity chromatography that the main material of the radioactivity excreted in urine in 5 h has the same properties as that of the administered heparin fraction.
- 公益社団法人日本薬学会の論文
著者
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OZEKI Shoji
Faculty of Pharmaceutical Sciences, Nagoya City University
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OZEKI Shoji
Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Nagoya City University
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Ozeki Shoji
Faculty Of Pharmaceutical Sciences Nagoya City University
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Iwamoto Kikuo
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:(present Ad
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Watanabe J
Department Of Pharmaceutics College Of Pharmacy Nihon University
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Watanabe Jun
Department Of Anatomy & Cell Science Kansai Medical University
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Hori Katsuyuki
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University
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