Search for Carrier-Mediated Transport Systems in the Rat Colon
スポンサーリンク
概要
- 論文の詳細を見る
Several nutrients and drugs, which are known to be absorbed by specific carrier-mediated transport systems in the small intestine, had their transport investigated in the rat colon, by measuring uptake into everted sacs, to find if carrier-mediated transport systems may also be present in the colon. Among those transported by Na^+-de-pendent carriers in the small intestine, D-glucose and taurocholate were found to be transported in an Na^+-de-pendent manner in the colon, while 5-fluorouracil and ascorbate were not. It was also found that the colonic transports of D-glucose and taurocholate were saturable. These results suggest the presence in the colon of Na^+-dependent carrier-mediated transport systems for D-glucose and taurocholate, but not for 5-fluorouracil and ascorbate. For nicotinate and methotrexate, which are transported by H^+-dependent carriers in the small intestine, their transport was elevated at a lower pH (5.0) than the pH 7.4 in the colon, but not saturable. Therefore, the elevated transport of these acidic compounds may be explained by an increase in passive flux due to an increase in the fraction of the unionized and/or neutral forms, without postulating the presence of H^+-dependent carrier-mediated transport systems in the colon. The transport activity of the suggested colonic transport systems for D-glucose and taurocholate was much lower than those of their respective counterparts in the small intestine. However, it may be possible to use them for oral drug delivery via the colon. Their physiological roles would also be of interest.
- 社団法人日本薬学会の論文
- 2003-02-01
著者
-
Hayashi Yoshie
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
-
Hayashi Yoshie
京都大学医学部附属病院 薬剤
-
林 弥生
College Of Pharmacy Kinjo Gakuin University
-
Watanabe J
School Of Pharmacy Aichi Gakuin University
-
INOUE Katsuhisa
Graduate School of Pharmaceutical Sciences, Nagoya City University
-
YUASA Hiroaki
Graduate School of Pharmaceutical Sciences, Nagoya City University
-
HAYASHI Yayoi
Graduate School of Pharmaceutical Sciences, Nagoya City University
-
WATANABE Jun
College of Pharmacy, Nihon University
-
TOMEI Shigemitsu
Graduate School of Pharmaceutical Sciences. Nagoya City University
-
TORIMOTO Mayumi
Graduate School of Pharmaceutical Sciences. Nagoya City University
-
OTA Yuri
Graduate School of Pharmaceutical Sciences, Nagoya City University
-
MORITA Kanako
Graduate School of Pharmaceutical Sciences, Nagoya City University
-
Inoue K
Gifu Pharmaceutical University
-
Ota Y
Graduate School Of Pharmaceutical Sciences Nagoya City University
-
Huang Ye
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
-
Yuasa H
Department Of Pharmaceutics And Drug Delivery School Of Pharmacy Tokyo University Of Pharmacy And Li
-
Morita K
Graduate School Of Pharmaceutical Sciences Nagoya City University
-
Morita Kanako
Graduate School Of Agriculture Kyoto University
-
Hayashi Yayoi
Graduate School Of Pharmaceutical Sciences Nagoya City University
-
Yuasa Hiroaki
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences Nagoya City University
-
Yuasa Hiroaki
Graduate School Of Pharmaceutical Sciences Nagoya City University
-
Watanabe J
Department Of Pharmaceutics College Of Pharmacy Nihon University
-
井上 勝央
名古屋市立大学大学院薬学研究科薬物動態制御学分野
-
Hayashi Y
Life Science Laboratories Central Research Laboratories Ajinomoto Co. Inc.:pharmaceuticals Research
-
Torimoto Mayumi
Graduate School Of Pharmaceutical Sciences Nagoya City University
-
Hayashi Yayoi
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University
-
Inoue Katsuhisa
Graduate School Of Pharmaceutical Sciences Nagoya City University
-
Tomei Shigemitsu
Graduate School Of Pharmaceutical Sciences Nagoya City University
-
Watanabe Jun
College Of Pharmacy Nihon University
関連論文
- Change in Taste Sensitivity to Sucrose Due to Physical Fatigue
- 01P1-144 ラットにおける経口投与後のnifedipineの消化管吸収に及ぼすカゼイ菌の影響(薬物相互作用(基礎と臨床),医療薬学の扉は開かれた)
- PCFT/SLC46A1による葉酸の吸収機構(ビタミン・バイオファクターのトランスポーター[II])
- Studies on Monoterpene Glucosides and Related Natural Products. XXIII. Biosynthesis of the Secoiridoid Glucosides, Gentiopicroside, Morroniside, Oleuropein, and Jasminin
- 42 イリドイド配糖体の酸化順序とloganinのセコイリドイド配糖体への環開裂の機構
- ラット腸管におけるビオチン輸送担体の機能解析
- Ca 拮抗剤アムロジピンの患者における Population Pharmacokinetics
- Studies on the Blue Pigments Produced from Genipin and Methylamine. II .On the Formation Mechanisms of Brownish-Red Intermediates Leading to the Blue Pigment Formation
- Studies on the Blue Pigments Produced from Genipin and Methylamine. I. Structures of the Brownish-Red Pigments, Intermediates Leading to the Blue Pigments
- 75 Genipinとアミノ酸より生成するPseudoazulene骨格をもつ青色々素の構造に関する研究
- Functional Characterization of Human Aquaporin 9 as a Facilitative Glycerol Carrier
- Absorption and Metabolic Extraction of Diltiazem from the Perfused Rat Small Intestine
- Saturable Absorption of Glycerol in the Rat Intestine(Biopharmacy)
- Kinetic Characterization of Carrier-Mediated Transport Systems for D-Glucose and Taurocholate in the Everted Sacs of the Rat Colon
- Search for Carrier-Mediated Transport Systems in the Rat Colon
- Effect of Maleylated Bovine Serum Albumin on the Disposition of Fractionated Heparin in Rats
- Uptake of FH by Two Types of Scavenger-Like Receptors in Rat Liver Parenchymal Cells in Primary Culture
- Uptake of Fractionated Heparin by Two Types of Scavenger Receptors in Isolated Rat Kupffer Cells
- Scavenger Receptor-Mediated Uptake of Fractionated [^3H] Heparin in Rat Peritoneal Macrophages
- First-Pass Metabolism of 5-Fluorouracil in the Perfused Rat Small Intestine
- Kinetic Characterization of Binding and Internalization of Fractionated [^3H]Heparin in Rat Liver Parenchymal Cells in Primary Culture
- Dose-Dependent Gastrointestinal Absorption of 5-Fluorouracil in Rats in Vivo
- Macromolecule-Macromolecule Interaction in Drug Distribution. V. Effects of Plasma Proteins on Uptake of Fractionated [^3H]Heparin in Isolated Rat Kupffer Cells
- Molecular Weight Dependency in the Uptake of Fractionated [^3H]Heparin in Isolated Rat Kupffer Cells
- Uptake Mechanism of Fractionated [^3H]Heparin in Isolated Rat Kupffer Cells : Involvement of Scavenger Receptors
- Macromolecule-Macromolecule Interaction in Drug Distribution. IV. Molecular Weight Dependency in the Interaction of Fractionated [^3H] Heparin with Plasma Proteins
- INTER-ORGAN RELATION BETWEEN SALIVARY GLAND AND KIDNEY IN LITHIUM EXCRETION UNDER CONTINUOUS STIMULATION OF SALIVATION IN DOGS : EFFECTS OF ORAL ADMINISTRATION OF NaCl OR KCl AND I.V. ADMINISTRATION OF SEVERAL DIURETICS ON LITHIUM CLEARANCES
- Inter-organ Relation between Salivary Gland and Kidney in Lithium Excretion. II. Salivary, Renal and Systemic Clearances of Lithium under Continuous Stimulation of Salivation in Water Loaded Dogs
- Investigation on Interaction of Fractionated ^3H-Heparin with Plasma Proteins by Gel Filtration Chromatography
- INTER-ORGAN RELATION BETWEEN SALIVARY GLAND AND KIDNEY IN LITHIUM EXCRETION : EFFECTS OF CONTINUOUS STIMULATION OF SALIVATION ON LITHIUM CLEARANCES IN DOGS
- ラット小腸におけるニフェジピンの初回通過代謝
- ラット小腸におけるグリセロールの担体輸送機構の解析
- ソフトカプセル用o/w乳剤タイプ新規基剤の開発 II 犬におけるビタミンK_2含有新規ソフトカプセル製剤の経口投与後の吸収特性
- ラットにおける5-フルオロウラシルの初回通過代謝 : 小腸と肝との相対的寄与
- 薬物の唾液中排泄(第48報)イヌにおけるトリメタジオンの唾液中排泄 - 最適唾液採取時間の検討 -
- ラットにおけるリチウムの腸管膜透過機構
- Effect of Glycerol-Related Compounds on Carrier-Mediated Glycerol Uptake in HCT-15 Human Colon Cancer Cell Line
- ラット小腸 in situ 一回灌流法による doxycycline の腸管吸収の解析
- アフリカツメガエル卵母細胞発現系における aquaporin 9 の glycerol 輸送機構の解析
- 薬物腸管吸収に及ぼすプロバイオティクスの影響を探る
- Carrier-Mediated Transport of Glycerol in the Perfused Rat Small Intestine(Biopharmacy)
- Glycerol Uptake in HCT-15 Human Colon Cancer Cell Line by Na^+-Dependent Carrier-Mediated Transport(Biopharmacy)
- Glycerol Absorption by Na^+-Dependent Carrier-Mediated Transport in the Closed Loop of the Rat Small Intestine(Biopharmacy)
- Functional Characterization of the Carrier-Mediated Transport System for Glycerol in Everted Sacs of the Rat Small Intestine(Biopharmacy)
- ラット肝実質細胞でのグリセロール担体輸送の解析
- ラット小腸刷子縁膜小胞におけるリボフラビンの担体輸送
- ラット腸管からのシクロスポリンのバイオアベイラビリティーの投与部位差
- Isolation of Oleayunnanoside from Fraxinus insularis and Revision of Its Structure to Insularoside-6′ -O-β-D-glucoside
- 42 数種のモクセイ科植物のセコイリドイド配糖体の構造と生合成(口頭発表の部)
- 分画ヘパリンの取り込みに関与するスカベンジャー受容体の多様性
- 遊離ラット小腸上皮細胞におけるriboflavinの担体輸送の解析
- ラット小腸におけるnifedipineの初回通過代謝の評価
- ラット小腸でのglycerolの輸送担体に及ぼすアルコール型薬物の影響
- 分画 heparin の体内動態におよぼす修飾ウシ血清アルブミンの影響 : in vivo と in vitro の関係
- 患者におけるアムロジピン錠投与後の体内動態の母集団解析
- 唾液中排泄における変動要因の研究 : TDMと医薬品開発のために
- ラットにおけるリチウム唾液中排泄に関する検討 : 水分負荷及びナトリウム負荷の影響
- Melting Granulation by Addition of Polyethyleneglycol for Stabilization of TAT-59
- Effects of Grinding and Tableting on Physicochemical Stability of an Anticancer Drug, TAT-59
- Anticancer Activity of Free γ-Linolenic Acid on AH-109A Rat Hepatoma Cells and the Effect of Serum Albumin on Anticancer Activity of γ-Linolenic Acid in Vitro
- Hydrolysis of 3', 5'-Dioctanoyl-5-fluoro-2'-deoxyuridine (FdUrd-C8) in Rabbit and Human Plasma and Its Release from Oily Solution
- Cellular Interaction and in Vitro Antitumor Activity of Lipophilic Mitomycin C Prodrugs(Pharmaceutical)
- Decreased Diuretic Response to Furosemide in Rats with Acute Hepatic Failure
- Increased Diuretic Response to Furosemide in Rats with Glycerol-Induced Acute Renal Failure
- URINARY EXCRETION AND DIURETIC RESPONSE TO FUROSEMIDE IN RATS AND HUMANS WITH RENAL INSUFFICIENCY
- Formation of Water-Insoluble Gel in Dry-Coated Tablets for the Controlled Release of Theophylline
- Application of Gel Formation for Taste Masking
- ラットにおけるリチウムの消化管吸収の制御
- Salivary Excretion of 5-Fluorouracil (5-FU). III. : Non-linear Kinetics of Salivary Excretion of 5-FU Following Bolus Intravenous Administration in Rats
- Dose-Dependent Salivary Excretion Following Bolus Intravenous Administration of Lithium in Dog
- Salivary Excretion of 5-Fluorouracil. I. Fluctuation of the Saliva/Plasma Concentration Ratio and Salivary Clearance in Beagle Dogs Following Bolus Intravenous Administration
- Studies on Production of Higher Functional Pharmaceutical Preparations by Using Various Additives. III. Application of Hollow Glass Beads for Intragastric Floating Granules
- Studies on the Development of Intragastric Floating and Sustained Release Preparation. I. Application of Calcium Silicate as a Floating Carrier
- Inter-organ Relation between Salivary Gland and Kidney in Lithium Excretion. IV. Saturation of Inhibitory Effect of NaCl on Ductal Reabsorption of Li^+ in Beagle Dogs
- Inter-organ Relation between Salivary Gland and Kidney in Lithium Excretion. III. Enhanced Salivary and Systemic Clearance of Li^+ by Oral Administration of NaCl in Dogs
- Salivary Excretion of 5-Fluorouracil (5-FU). V. Effect of 5-FU Concentration in Perfusate on the Salivary Excretion of 5-FU in Perfused Rat Mandibular Gland
- 22B-15 ラットにおける 5-フルオロウラシルの生物学的利用率の変動性に関する検討
- Quantitative Investigation of the Effect of Sensory Nerve Anesthesia with 9% Lidocaine Ointment on Healthy Subjects by Use of the Neuroselective Current Perception Threshold
- Dissolution Tests for Self-Setting Calcium Phosphate Cement-Containing Nifedipine
- L-Theanine Elicits an Umami Taste with Inosine 5′-Monophosphate
- Investigation on the Influx Transport Mechanism of Pentazocine at the Blood-Brain Barrier in Rats Using the Carotid Injection Technique(Biopharmacy)
- Pharmacokinetic/Pharmacodynamic Relationship of Eptazocine, a Narcotic-Antagonist Analgesic, in Rats
- Involvement of P-glycoprotein in Blood-Brain Barrier Transport of Pentazocine in Rats Using Brain Uptake Index Method(Biopharmacy)
- Application of Carbopol^ to Controlled Release Preparations. II. Controlled Release by Use of Carbopol^ as a Matrix Material, as a Coating Material, and as Both
- Identification and Functional Characterization of Rat Riboflavin Transporter 2
- Fractional Absorption of L-Carnitine after Oral Administration in Rats : Evaluation of Absorption Site and Dose Dependency
- Dose Dependency in the Gastrointestinal Absorption of Cefatrizine : Correlation between in Vivo and in Situ
- In Vitro and ex Vivo Ca-Antagonistic Effect of 2-Methoxyethyl (E)-3-phenyl-2-propen-1-yl (±)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl) pyridine-3,5-dicarboxylate (FRC-8653), a New Dihydropyridine Derivative
- Effects of a New Dihydropyridine Derivative, FRC-8653,on Blood Pressure in Conscious Spontaneously Hypertensive Rats
- Emulsion Type New Vehicle for Soft Gelatin Capsule Available for Preclinical and Clinical Trials : Stabilization of New Vehicle Containing Vitamin K_2 with PEG 6000
- Emulsion Type New Vehicle for Soft Gelatin Capsule Available for Preclinical and Clinical Trials : Effects of PEG 6000 and PVP K30 on Physicochemical Stability of New Vehicle
- Emulsion Type New Vehicle Available for Preclinical and Clinical Trials : Stability of Characteristics of Particle Size Distribution of New Vehicle
- Development of Emulsion Type New Vehicle for Soft Gelatin Capsule. I. Selection of Surfactants for Development of New Vehicle and Its Physicochemical Properties
- Metabolic Extraction of Nifedipine during Absorption from the Rat Small Intestine
- Are Novel Scavenger-Like Receptors Involved in the Hepatic Uptake of Heparin ?
- Influence of Prolonged Exercise on Sweet Taste Perception
- L-Theanine Elicits an Umami Taste with Inosine 5'-Monophosphate
- Salivary Excretion of 5-Fluorouracil (5-FU). IV. Dependency of Saliva/Plasma Concentration Ratio and Salivary Clearance on Plasma Concentration of 5-FU during Constant-Rate Intravenous Infusion in Rats
- Inter-organ Relation between Salivary Gland and Kidney in Lithium Excretion. I. Effects of Continuous Stimulation of Salivation on Salivary, Renal and Systemic Clearances of Lithium in Dog
- Salivary Excretion of 5-Fluorouracil. II. Fluctuation of Saliva/Plasma Concentration Ratio and Salivary Clearance during a Constant Rate Intravenous Infusion in Beagle Dogs