Inter-organ Relation between Salivary Gland and Kidney in Lithium Excretion. III. Enhanced Salivary and Systemic Clearance of Li^+ by Oral Administration of NaCl in Dogs

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Effects of oral administration of NaCl on salivary and systemic clearance of Li^+ were investigated following bolus intravenous administration of LiCl in male beagle dogs. Fifty ml of NaCl solution (100meq/l) was administered orally 7 times at 1h intervals. Gustatory stimulation was continued for 390min using citric acid solution. Saliva was collected by means of permanent fistulae for parotid and mandibular-sublingual glands. Salivary clearance of Li^+ was markedly increased by continuous stimulation of salivation, and was enhanced further after oral administration of NaCl solution. Renal clearance of Li^+ showed a decreasing tendency under continuous salivation compared with the condition without gustatory stimulation; however, this decreasing tendency disappeared after oral administration of NaCl solution. Consequently, systemic clearance of Li^+ was increased due to the contribution of increased salivary clearance. Enhancement of Salivary Li^+ clearance after administration of NaCl suggests the salivary excretion mechanism of Li^+ may include a reabseoption process, like its renal excretion. Administration of NaCl solution had similar effects on salivary and systemic clearances of K^+ to those on Li^+ clearances, and a significant correlation was observed between Li^+ and K^+ clearances of both salizary gland and kidney.
公益社団法人日本薬学会の論文
1990-12-25