Effect of Convulsions Induced by Pentylenetetrazole or Electricity on the Dispositions of Creatinine and Urea in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The effect of convulsions on teh dispositions of creatinine and urea, which are considered to pass through the water-filled pores of biological membranes easily, was examined by means of plasma analysis and whole-body autoradiography following intravenous administration of each compound to rats during tonic convulsions induced by pentylenetetrazole or electricity. The data on the plasma levels showed that, in convulsed rats, the transfer of creatinine and urea from plasma to tissues was suppressed and the total body clearance of both chemicals was significantly decreased. The results of whole-body autoradiography, which showed decreased or almost stopped blood flow in the intestinal tract, skin, and kidney of convulsed rats, were in good agreement with the above observations.
- 公益社団法人日本薬学会の論文
- 1984-07-25
著者
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渡辺 淳
日本大・薬
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渡辺 淳
Department of Biopharmaceutics, Faculty of Pharmaceutical Science, Nagoya City University
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平手 純司
Department of Biopharmaceutics, Faculty of Pharmaceutical Science, Nagoya City University
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尾関 昭二
Department of Biopharmaceutics, Faculty of Pharmaceutical Science, Nagoya City University
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渡辺 淳
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University
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尾関 昭二
Faculty Of Pharmaceutical Sciences Nagoya City University
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平手 純司
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University
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