Relationship between Partition Coefficients and Apparent Volumes of Distribution for Basic Drugs. II
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概要
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According to the previously proposed model for drug distribution in the body, the apparent volumes of distribution (V_d') of basic drugs with high apparent partition coefficients (P') were related to the blood plasma volume, the other non-lipid space, and the lipid space. The logarithm of V_d' values for basic drugs with P' of 3.2×10^0-6.7×10^2 had good correlation (r=0.937) with the logarithm of P'values. The relationship between V_d' and P' was estimated in the region of both low and high P'. The comparison of the result with the observed values indicated that the proposed model was considerably satisfactory, but that there were some other factors which fluctuated the values of V_d'.
- 公益社団法人日本薬学会の論文
- 1978-11-25
著者
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渡辺 淳
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University
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渡辺 淳
Faculty of Pharmaceutical Sciences, Nagoya City University
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小崎 章夫
Faculty of Pharmaceutical Sciences, Nagoya City University
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小崎 章夫
Faculty Of Pharmaceutical Sciences Nagoya City University
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