Absorption and Distribution of Creatinine and Urea in Hereditary Muscular Dystrophic Mice
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概要
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The absorption and distribution of creatinine and urea, which are considered to pass through the water-filled pores of biological membranes easily, were investigated in hereditary muscular dystrophic mice as model animals afflicted with a disease which changes the structure and function of the cell membrane. The V_<d'extrap> for creatinine was remarkably larger in dystrophic mice than that of the control. Whole-body autoradiograms showed that creatinine was distributed rather more uniformly throughout the body in dystrophic mice than in the control at 2 min. A similar, but less pronounced, tendency was also observed in the case of urea. For both chemicals, the urinary excretion of radioactivity in 24 h following oral administration was significantly larger in dystrophic mice than in the control (p<0.02). The above results indicated that the membrane permeability to these two chemicals was enhanced by the disease.
- 公益社団法人日本薬学会の論文
- 1981-11-25
著者
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岩本 喜久生
Department Of Biopharmaceutics Faculty Of Pharmaceutial Science Nagoya City University
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渡辺 淳
Department of Biopharmaceutics, Faculty of Pharmaceutical Science, Nagoya City University
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平手 純司
Department of Biopharmaceutics, Faculty of Pharmaceutical Science, Nagoya City University
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尾関 昭二
Department of Biopharmaceutics, Faculty of Pharmaceutical Science, Nagoya City University
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渡辺 淳
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University
-
尾関 昭二
Faculty Of Pharmaceutical Sciences Nagoya City University
-
平手 純司
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University
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