Inter-Strain Differences of Exogeneous Creatinine Disposition in Rats and Mice

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Inter-strain differences of exogeneous creatinine disposition in rats and mice were assessed by comparing the plasma or whole blood level-time data following intravenous administration to rats (Wistar, Sprague-Dawley, F344,ACI and Donryu strains) and mice (ddY and C57BL/6 strains). Almost all pharmacokinetic parameters were about the same among all the strains of rats studied, and this was also the case for mice. However, non-negligible and statistically significant differences were observed in (V'_d)_<extrap> values. For example, the (V'_d)_<extrap> value for F344 rats (4.62×10^3±7.38×10^2ml/kg) was about 1.7 times that for Donryu rats (2.75×10^3±2.99×10^2ml/kg) (p<0.01). Similarly, the value for C57BL/6 mice (2.77×10^3±5.04×10^2ml/kg) was about twice that for ddY mice (1.35×10^3±4.63×10^2ml/kg) (p<0.01). This result for mice was consistent with the whole-body autoradiographic data. These findings suggest that the distribution properties of creatinine vary among different strains of rats and mice.
公益社団法人日本薬学会の論文
1985-08-25