Activation by α_1-Adrenergic Agonists of the Progression Phase in the Proliferation of Primary Cultures of Smooth Muscle Cells in Mouse and Rat Aorta

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The effects of catecholamines on the competence and progression phases in the proliferation of vascular smooth muscle cells (SMCs) in mouse and rat were investigated in primary cultures. α, β-Adrenergic agonists such as epinephrine and norepinephrine, and the α-adrenergic agonist, phenylephrine, stimulated proliferation of primary cultured SMCs, whereas the α_2-adrenergic agonist, clonidine, and β-adrenergic agonist, isoproterenol, did not. The stimulating effect of epinephrine was maximal at 0.54μM and was then decreased at higher concentrations. The α-adrenergic antagonist, phentolamine, and α_1-adrenergic antagonist, prazosin, inhibited epinephrine-induced SMC proliferation, while the α_2-adrenergic antagonist, yohimbine, and β-adrenergic antagonist, propranolol, did not. In primary cultured and synchronized SMCs at the G_0 phase, norepinephrine accelerated the rate of SMC proliferation, but did not change the starting time of DNA synthesis and proliferation. These results show that catecholamines activate the progression phase in primary cultured aortic SMCs α_1-adrenergic receptors.
社団法人日本薬学会の論文
1995-10-15