The Effect of Sacrificing Method on the Tissue Concentration of Exogeneous Creatinine in Rats

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概要

• 論文の詳細を見る

• The effect of sacrificing method on the apparent tissue concentration of creatinine, which is affected by the blood content of the tissue, was evaluated following the intravenous administration of creatinine to rats. Two methods were compared : the freezing method and the decapitation technique. At 5 min following the administration, the creatinine concentrations in the brain and myocardium of the decapitated rats were significantly (p < 0.05) lower than those of the frozen rats. This might result from the difference of blood contents in these tissues between the two groups of rats. Thus, the experimental method for collecting tissues can affect the brain and myocardium concentrations of [^<14>C] creatinine administered to rats.

• 公益社団法人日本薬学会の論文
• 1985-11-25

著者

• 渡辺 淳

  日本大・薬

• 堀越 勇

  Department of Hospital Pharmacy, Toyama Medical and Pharmaceutical University

• 渡辺 淳

  Department of Biopharmaceutics, Faculty of Pharmaceutical Science, Nagoya City University

• 平手 純司

  Department of Biopharmaceutics, Faculty of Pharmaceutical Science, Nagoya City University

• 尾関 昭二

  Department of Biopharmaceutics, Faculty of Pharmaceutical Science, Nagoya City University

• 堀 勝行

  Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University

• 渡辺 淳

  Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University

• 尾関 昭二

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 堀越 勇

  Department Of Hospital Pharmacy Toyama Medical And Pharmaceutical University

• 平手 純司

  富山医科薬科大学附属病院薬剤部

• 平手 純司

  Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University

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