Relationship between Partition Coefficients and Apparent Volumes of Distribution for Basic Drugs. I
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概要
- 論文の詳細を見る
The model was proposed to relate the apparent volume of distribution (V_d') of a drug to the apparent partition coefficient (P') and the volume of blood plasma. It was found that V_d'values for basic drugs were almost constant in the region of low P'and that V_d'increases in the region of high P'. The average V_d'value (1.47 l/kg) for basic drugs with low P'was about thirty times larger than the value of the blood plasma volume (0.05 l/kg).
- 公益社団法人日本薬学会の論文
- 1978-02-25
著者
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渡辺 淳
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University
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渡辺 淳
Faculty of Pharmaceutical Sciences, Nagoya City University
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小崎 章夫
Faculty of Pharmaceutical Sciences, Nagoya City University
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小崎 章夫
Faculty Of Pharmaceutical Sciences Nagoya City University
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