Determination of Perisoxal and Its Phenolic Metabolites in Rat, Rabbit and Human Urine

概要

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After a single administration of perisoxal citrate to rats (21 mg/kg, i. v.), rabbits (15 mg/kg, i. v.) and humans (200 mg/man, p. o.), urinary excretion of the unchanged drug and its phenolic metabolites and the glucuronide forms of all these compounds was determined by a newly developed specific and simultaneous GC method. Generally, in all the species examined, excretion of the free forms of perisoxal and hydroxyperisoxals (m- and p-) was low or even undetectable, but that of the glucuronide forms was high. Neither the free nor the glucuronide form of o-hydroxyperisoxal was detected. The proportion of total m-hydroxy metabolites to total p-hydroxy metabolites varied in different species, being about 3 in rats, about 0.4 in rabbits and less than 0.1 in humans.
公益社団法人日本薬学会の論文
1980-07-25