Difference in Saliva : Plasma Concentration Ratio of Endogenous Urea between Mandibular and Parotid Glands in Dogs

概要

論文の詳細を見る
The difference in saliva/plasma concentration ratio (S/P ratio) of urea between mandibular and parotid glands in dogs was investigated in detail by a technique of retrograde ductal injection of HgCl_2. In every dog, four kinds of saliva [untreated(control) mandibular and parotid saliva, HgCl_2-treated mandibular and parotid saliva] were collected under pilocarpine stimulation of salivation. The following results were obtained. (1) It was verified in this study that S/P ratios of urea and Na^+ were significantly increased in HgCl_2-treated mandibular saliva. (2)S/P ratios of urea and Na^+ in HgCl_2-treated parotid saliva were also significantly higher than those in untreated saliva. These results suggested that parotid salivary urea is also reabsorbed in the striated duct do dogs. (3) In untreated glands, the mean C_<Pr>/C_M ratio of urea (the ratio of urea concentration in parotid saliva to that in mandibular saliva) was about 1.65. This ratio tended to decrease toward unity in the HgCl_2-treated gland. Therefore, it was suggested that the striated duct might play an important role in the gland-specific difference of S/P ratios of urea between the salivary glands of dog.
社団法人日本薬学会の論文
1988-12-25