Gastric Emptying-Limited Oral Absorption of α-Linolenic Acid Administered as a Milk Fat-Globule Membrane (MFGM) Emulsion in Rats

概要

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As a study to assess the potential application of milk fat-globule membrane (MFGM), which is of natural origin and expected to be a safer alternative to synthetic emulsifiers, to pharmaceutical dosage forms, the oral absorption of α-linolenic acid was evaluated by the analysis of gastrointestinal disposition after oral administration as an MFGM emulsion to rats. A linear model incorporated with first-order gastric emptying followed by first-order intestinal absorption was fitted to the data of the remaining fraction of α-linolenic acid versus time profiles for the stomach and small intestine to estimate the rate constants of gastric emptying (k_g) and intestinal absorption (k_a). The k_a (0.045 min^<-1>) was about 4 times larger than the k_g (0.011 min^<-1>). The k_g was comparable to the apparent oral absorption rate constant estimated by the pharmacokinetic analysis of plasma concentration data. These results suggest that the oral absorption of α-linolenic acid administered as MFGM emulsion is gastric emptying-limited and, hence, any change in the intestinal absorption process would only modestly affect its oral absorption.
公益社団法人日本薬学会の論文
1994-09-15