Dose-Dependent Salivary Excretion Following Bolus Intravenous Administration of Lithium in Dog

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Salivary excretion of lithium was investigated following bolus intravenous administration at low or high dose (0.145 or 1.45 meq/kg) to beagle dogs. Salivation was stimulated with 10% citric acid. Parotid saliva (Pr) and mandibular-sublingual saliva (MS) were collected separately by means of permanent fistulae. (1) The concentrations of lithium in both saliva and plasma declined biexponentially with time at both dose levels. (2) The lithium concentrations in each saliva were higher than and well correlated to those in plasma at both dose levels. (3) The saliva/plasma lithium concentration ratios (S/P ratios; Pr 2.19,MS 1.59) at high dose were significantly higher than those (Pr 1.64,MS 1.35) at low dose in the Pr and MS (P<0.001). (4) The S/P ratio and salivary clearance (CL_s) of lithium slightly increased with the plasma concentration of the drug. These results suggested that salivary excretion of lithium depended on the dose level or the plasma concentration. (5) CL_s of lithium was well correlated to that of sodium or potassium at both dose levels. The CL_s values of lithium and potassium at high dose were greater than those at low dose, but the CL_s of sodium remained unchanged at the two doses. (6) Mean total salivary clearance [(CL_<Pr>+CL_<MS>)×2] of lithium was about 70% and 60% of its total body clearance at low and high doses, respectively.
公益社団法人日本薬学会の論文
1988-08-25