Hepatic Transport of an Antiallergic Agent, Emedastine Difumarate : Interspecies Difference in Rats and Guinea Pigs
スポンサーリンク
概要
- 論文の詳細を見る
Interspecies differences in the hepatic transport of an antiallergic agent, emedastine difumarate (KG-2413), were investigated in rats and guinea pigs, taking notice of the influx, efflux and metabolic processes. When the concentration of emedastine in the injection was varied from 2μM to 10mM, the extraction ratio of total radioactive compound to the liver at 18s in rats and 25s in guinea pigs after the rapid portal injection was more than 90% of the dose. This suggested that the influx velocity of emedastine into the liver was extremely fast, and that there was no interspecies difference in the influx process. The disappearance of unchanged emedastine from the liver was described by biexponential curve in rats and monoexponential curve in guinea pigs after rapid portal injection of 100μM solution. This difference might be related to the interspecies difference in the binding of emedastine to the liver tissue. The time courses of disappearance of total radioactive compound and unchanged emedastine from the liver were analyzed using a compartment model for the examination of the efflux and metabolic processes. Emedastine was observed to have a pronounced interspecies difference in metabolic rate constant, but there was no pronounced interspecies difference in its efflux rate constant.
- 公益社団法人日本薬学会の論文
- 1990-05-25
著者
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渡辺 淳
Department of Biopharmaceutics, Faculty of Pharmaceutical Science, Nagoya City University
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粟田 則男
Pharmaceutical Research Center, Kanebo, Ltd.
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渡辺 淳
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University
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粟田 則男
鐘紡株式会社薬品開発研究所
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粟田 則男
Department Of Formulation Research Pharmaceuticals Research Center Kanebo Ltd.
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粟田 則男
Product Research And Development Laboratories Pharmaceuticals Research Center Kanebo Ltd.
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粟田 則男
鐘紡株式会社薬品研究所
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酒井 孝範
鐘紡株式会社薬品開発研究所
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酒井 孝範
Pharmaceuticals Research Center, Kanebo, Ltd.,
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