Determination of the Antiallergic Agent KB-2413 in Plasma by Means of Capillary Gas Chromatography with a Nitrogen-Sensitive Detector
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概要
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A gas chromatographic method for the quantitative determination of the new antiallergic agent, 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazole difumarate (KB-2413), in plasma has been developed. This method, which was based on solvent extraction and flexible fusedsilica capillary gas chromatography with a nitrogen-sensitive detector and a moving needle solvent cut sample injector, is simple, sensitive and selective.The detection limit was about 1 ng (as free base)/ml and the calibration curve was linear over the range of 2 to 100 ng/ml. Moreover, the intra- and inter-assay coefficients of variation for the determination of KB-2413 were 3.1-4.0% and 1.5-6.7%, respectively. This assay was applied to the determination of the plasma concentration of KB-2413 base after oral administration to dogs.
- 公益社団法人日本薬学会の論文
- 1986-03-25
著者
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中村 百合子
Pharmaceuticals Research Center Kanebo Ltd.
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粟田 則男
Pharmaceutical Research Center, Kanebo, Ltd.
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粟田 則男
鐘紡株式会社薬品開発研究所
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粟田 則男
Department Of Formulation Research Pharmaceuticals Research Center Kanebo Ltd.
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粟田 則男
Product Research And Development Laboratories Pharmaceuticals Research Center Kanebo Ltd.
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粟田 則男
鐘紡株式会社薬品研究所
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浜田 司
鐘紡株式会社薬品研究所
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浜田 司
Pharmaceuticals Research Center, Kanebo, Ltd.,
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門脇 正名
Pharmaceuticals Research Center, Kanebo, Ltd.,
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門脇 正名
鐘紡
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