High-Performance Liquid Chromatographic Determination of Ferulic Acid in Plasma
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概要
- 論文の詳細を見る
A simple, rapid and sensitive reversed-phase high performance liquid chromatographic (HPLC) method for the quantitative determination of ferulic acid in plasma was developed. Ferulic acid in plasma was extracted with ethyl ether, separated on a reversed-phase C_<18> column with a mixture of acetonitrile and 0.1м acetic acid (1 : 3,v/v) as a mobile phase, and quantitated by ultraviolet (UV) absorbance measurement at 313nm. 3,4-Dimethoxycinnamic acid was used as an internal standard. The detection limit (signal-to-noise ratio=3) and the mean recovery from plasma were 1 ng (as amount injected) and 99.5±3.3%, respectively. The plasma levels of ferulic acid following oral administration of γ-oryzanol were determined by the present method and the mass fragmentographic (MF) method. A close correlation between the results of HPLC and those of MF was observed (γ=0.988). The present HPLC method was found to be applicable to the determination of ferulic acid in plasma in place of the MF method.
- 公益社団法人日本薬学会の論文
- 1983-03-25
著者
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藤原 茂
鐘紡(株)薬品研究所
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杉本 功
Department of Pharmacy, Kitano Hospital
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杉本 功
(present Address)department Of Pharmacy Kitano Hpspital
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杉本 功
Department Of Pharmacy Kitano Hospital
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粟田 則男
鐘紡株式会社薬品開発研究所
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粟田 則男
Department Of Formulation Research Pharmaceuticals Research Center Kanebo Ltd.
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粟田 則男
Product Research And Development Laboratories Pharmaceuticals Research Center Kanebo Ltd.
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粟田 則男
鐘紡株式会社薬品研究所
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浜田 司
鐘紡株式会社薬品研究所
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浜田 司
Department of Formulation Research, Pharmaceuticals Research Center, Kanebo, Ltd.
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杉本 功
Pharmaceuticals Research Center Kanebo Ltd.
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