Contributions of Various Serum Proteins to the Binding of Prasterone Sulfate in Humans
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概要
- 論文の詳細を見る
The binding of prasterone sulfate (PS) in human plasma was investigated. Binding percentages of PS to human plasma, human serum albumin (HSA), human α_1-acid glycoprotein (AGP) and human γ-globulin (GGL) were independent of the PS concentration between 0.1 and 8.0 μg/ml. The mean binding percentages were 99.1% for human plasma, 98.3% for HSA, 12.6% for AGP and 8.1% for GGL. Though PS is an acidic drug, binding of PS to AGP was observed. From the binding index, it was found that PS mainly bound to HSA in human plasma and that the contributions of AGP and GGL to PS in plasma were negligible.
- 公益社団法人日本薬学会の論文
- 1992-10-25
著者
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粟田 則男
鐘紡株式会社薬品開発研究所
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粟田 則男
Department Of Formulation Research Pharmaceuticals Research Center Kanebo Ltd.
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粟田 則男
Product Research And Development Laboratories Pharmaceuticals Research Center Kanebo Ltd.
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粟田 則男
鐘紡株式会社薬品研究所
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酒井 孝範
鐘紡株式会社薬品開発研究所
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酒井 孝範
Product Research and Development Laboratories, Pharmaceuticals Research Center, Kanebo, Ltd.,
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安達 佳子
Product Research and Development Laboratories, Pharmaceuticals Research Center, Kanebo, Ltd.,
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弥富 美佳
Product Research and Development Laboratories, Pharmaceuticals Research Center, Kanebo, Ltd.,
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安達 佳子
Product Research And Development Laboratories Pharmaceuticals Research Center Kanebo Ltd.
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弥富 美佳
Product Research And Development Laboratories Pharmaceuticals Research Center Kanebo Ltd.
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