Isolation of Perisoxal Glucuronides and Determination of Enantiomeric Ratios of d-and l-Perisoxal Metabolites excreted in Rabbit Urine
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概要
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Perisoxal glucuronides were isolated from rabbit urine after repeated subcutaneous administration of dl-perisoxal citrate. Optical rotatory analysis of free bases obtained from the glucuronides indicated that about twice as much d-perisoxal glucuronide as l-isomer was formed. Stereoselective metabolism was observed in rabbit urine after d- or l-perisoxal administration. d-Perisoxal glucuronide was excreted predominantly at doses of 1.8 and 9.0 mg/kg. The excretions of d- and l-isomers of p-hydroxyperisoxal glucuronides were similar at the dose of 9.0 mg/kg, but a larger value was obtained for the l-isomer at the dose of 1.8 mg/kg.
- 公益社団法人日本薬学会の論文
- 1981-12-25
著者
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岡部 博
Shionogi Research Laboratory Shionogi And Co. Ltd.
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渡辺 淳
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University
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渡辺 淳
Faculty of Pharmaceutical Sciences, Nagoya City University
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山本 恵津子
Pharmaceutical Institute Tohoku University
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中島 善次
Shionogi Research Laboratory Shionogi And Co. Ltd.
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菅野 浩一
Shionogi Research Laboratory Shionogi And Co. Ltd.
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溝尻 顕爾
Shionogi Research Laboratory Shionogi And Co. Ltd.
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山本 恵津子
Shionogi Research Laboratory, Shionogi and Co., Ltd.
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