唾液中排泄における変動要因の研究 : TDMと医薬品開発のために
スポンサーリンク
概要
- 論文の詳細を見る
- 社団法人日本薬学会の論文
- 1998-02-01
著者
-
渡辺 淳
日本大・薬
-
渡邉 淳
日本大薬
-
渡邉 淳
日本大・薬
-
林 弥生
College Of Pharmacy Kinjo Gakuin University
-
林 弥生
名古屋市立大学 大学院薬学研究科 薬物動態制御学研究室
-
渡邉 淳
名古屋市立大学薬学部薬剤学教室
-
Hayashi Y
Life Science Laboratories Central Research Laboratories Ajinomoto Co. Inc.:pharmaceuticals Research
-
Hayashi Yayoi
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University
関連論文
- Factors Affecting the in Vitro Stability of ^C-Urea in the Urine of Rats
- 01P1-144 ラットにおける経口投与後のnifedipineの消化管吸収に及ぼすカゼイ菌の影響(薬物相互作用(基礎と臨床),医療薬学の扉は開かれた)
- 可視光応答型酸化チタンの歯科領域への応用
- ペンタゾシン含有リン酸カルシウムセメント製剤特性に及ぼす粉液比の影響
- ハイドロキシアパタイト系製剤におけるペンタゾシンの脳内濃度推移の評価
- 頸動脈注入法を用いたペンタゾシンの血液脳関門輸送の解析
- アパタイトセメントを基剤とした製剤の各種溶出試験法による溶出推移
- ソフトカプセル用o/w乳剤タイプ新規基剤の開発 I ビタミンK2含有新規基剤の製剤学的評価
- ラット腸管におけるビオチン輸送担体の機能解析
- Macromolecule-Macromolecule Interaction in Drug Distribution. III. Kinetic Characterization of the Uptake of Fractionated [^3H]Heparin and the Effect of Plasma Proteins in the Perfused Rat Liver
- Ca 拮抗剤アムロジピンの患者における Population Pharmacokinetics
- Functional Characterization of Human Aquaporin 9 as a Facilitative Glycerol Carrier
- Absorption and Metabolic Extraction of Diltiazem from the Perfused Rat Small Intestine
- Saturable Absorption of Glycerol in the Rat Intestine(Biopharmacy)
- Kinetic Characterization of Carrier-Mediated Transport Systems for D-Glucose and Taurocholate in the Everted Sacs of the Rat Colon
- Search for Carrier-Mediated Transport Systems in the Rat Colon
- Effect of Maleylated Bovine Serum Albumin on the Disposition of Fractionated Heparin in Rats
- Uptake of FH by Two Types of Scavenger-Like Receptors in Rat Liver Parenchymal Cells in Primary Culture
- Uptake of Fractionated Heparin by Two Types of Scavenger Receptors in Isolated Rat Kupffer Cells
- Scavenger Receptor-Mediated Uptake of Fractionated [^3H] Heparin in Rat Peritoneal Macrophages
- First-Pass Metabolism of 5-Fluorouracil in the Perfused Rat Small Intestine
- Kinetic Characterization of Binding and Internalization of Fractionated [^3H]Heparin in Rat Liver Parenchymal Cells in Primary Culture
- Dose-Dependent Gastrointestinal Absorption of 5-Fluorouracil in Rats in Vivo
- Macromolecule-Macromolecule Interaction in Drug Distribution. V. Effects of Plasma Proteins on Uptake of Fractionated [^3H]Heparin in Isolated Rat Kupffer Cells
- Molecular Weight Dependency in the Uptake of Fractionated [^3H]Heparin in Isolated Rat Kupffer Cells
- Uptake Mechanism of Fractionated [^3H]Heparin in Isolated Rat Kupffer Cells : Involvement of Scavenger Receptors
- Macromolecule-Macromolecule Interaction in Drug Distribution. IV. Molecular Weight Dependency in the Interaction of Fractionated [^3H] Heparin with Plasma Proteins
- INTER-ORGAN RELATION BETWEEN SALIVARY GLAND AND KIDNEY IN LITHIUM EXCRETION UNDER CONTINUOUS STIMULATION OF SALIVATION IN DOGS : EFFECTS OF ORAL ADMINISTRATION OF NaCl OR KCl AND I.V. ADMINISTRATION OF SEVERAL DIURETICS ON LITHIUM CLEARANCES
- Inter-organ Relation between Salivary Gland and Kidney in Lithium Excretion. II. Salivary, Renal and Systemic Clearances of Lithium under Continuous Stimulation of Salivation in Water Loaded Dogs
- Investigation on Interaction of Fractionated ^3H-Heparin with Plasma Proteins by Gel Filtration Chromatography
- INTER-ORGAN RELATION BETWEEN SALIVARY GLAND AND KIDNEY IN LITHIUM EXCRETION : EFFECTS OF CONTINUOUS STIMULATION OF SALIVATION ON LITHIUM CLEARANCES IN DOGS
- ラット小腸におけるニフェジピンの初回通過代謝
- ラット小腸におけるグリセロールの担体輸送機構の解析
- ムコ多糖類のスカベンジャー受容体介在性細胞取り込みの薬物動態学的解析
- ソフトカプセル用o/w乳剤タイプ新規基剤の開発 II 犬におけるビタミンK_2含有新規ソフトカプセル製剤の経口投与後の吸収特性
- 血漿タンパク存在下でのラット培養肝実質細胞における分画 heparin の表面結合と内在化の分子量依存性
- ラット培養肝実質細胞による分画[^3H]Heparin の代謝及び放出の検討
- ラットにおける5-フルオロウラシルの初回通過代謝 : 小腸と肝との相対的寄与
- ラットにおける水溶性低分子薬物の腸管膜透過 : 小腸と大腸との比較および解剖学的要因との関係
- ラット in vivo におけるリボフラビンの非線形消化管吸収の解析
- ラットにおける非線形消化管吸収の生理機構論的解析 : in vitro-in vivo 相関の検討および吸収予測への応用
- 13-6-33 ソフトカプセル用新規基剤の開発
- ラット肝実質細胞における分画heparinの輸送機構:スカベンジャー様レセプターの関与
- 薬物の唾液中排泄(第48報)イヌにおけるトリメタジオンの唾液中排泄 - 最適唾液採取時間の検討 -
- ラットにおけるリチウムの腸管膜透過機構
- 大腸における[^3H]Inulinの部位特異的分解を利用した小腸通過時間の評価
- ラットにおける小腸-大腸間の膜透過性の比較
- 分画[^3H]Heparinの体内動態における分子量依存性及び投与量依存性
- ラット遊離クッパー細胞による分画ヘパリン輸送機構:スカベンジャー受容体の関与
- Effect of Glycerol-Related Compounds on Carrier-Mediated Glycerol Uptake in HCT-15 Human Colon Cancer Cell Line
- ラット小腸 in situ 一回灌流法による doxycycline の腸管吸収の解析
- アフリカツメガエル卵母細胞発現系における aquaporin 9 の glycerol 輸送機構の解析
- 薬物腸管吸収に及ぼすプロバイオティクスの影響を探る
- Carrier-Mediated Transport of Glycerol in the Perfused Rat Small Intestine(Biopharmacy)
- Glycerol Uptake in HCT-15 Human Colon Cancer Cell Line by Na^+-Dependent Carrier-Mediated Transport(Biopharmacy)
- Glycerol Absorption by Na^+-Dependent Carrier-Mediated Transport in the Closed Loop of the Rat Small Intestine(Biopharmacy)
- Functional Characterization of the Carrier-Mediated Transport System for Glycerol in Everted Sacs of the Rat Small Intestine(Biopharmacy)
- ラット肝実質細胞でのグリセロール担体輸送の解析
- ラット小腸刷子縁膜小胞におけるリボフラビンの担体輸送
- ラット腸管からのシクロスポリンのバイオアベイラビリティーの投与部位差
- ラットにおけるnifedipineの初回通過代謝におけるセロトニンの役割
- 分画ヘパリンの取り込みに関与するスカベンジャー受容体の多様性
- 遊離ラット小腸上皮細胞におけるriboflavinの担体輸送の解析
- ラット小腸におけるnifedipineの初回通過代謝の評価
- ラット小腸でのglycerolの輸送担体に及ぼすアルコール型薬物の影響
- 分画 heparin の体内動態におよぼす修飾ウシ血清アルブミンの影響 : in vivo と in vitro の関係
- 患者におけるアムロジピン錠投与後の体内動態の母集団解析
- 唾液中排泄における変動要因の研究 : TDMと医薬品開発のために
- ラットにおけるリチウム唾液中排泄に関する検討 : 水分負荷及びナトリウム負荷の影響
- 14-2-21 分画 Heparin の体内動態と血液凝固阻止作用における分子量依存性
- Difference in Saliva : Plasma Concentration Ratio of Endogenous Urea between Mandibular and Parotid Glands in Dogs
- Role of the Main Mandibular Excretory Duct in Salivary Excretion of Urea in Dogs
- Uptake of Low Molecular Weight Fractionated [^3H] Heparin by Rat Hepatocytes in the Primary Culture
- Uptake of Fluorescein Isothiocyanate (FITC)-Fractionated Heparin by Rat Parenchymal Hepatocytes in Primary Culture
- Macromolecule-Macromolecule Interaction in Drug Distribution. II. Effect of α-Glubulin on Saturable Uptake of Fractionated [^3H]Heparin by Rat Parenchymal Hepatocytes in Primary Culture
- Macromolecule-Macromolecule Interaction in Drug Distribution : Effect of α-Globulin Concentration on the Hepatic Uptake of Fractionated ^3H-heparin by Perfused Rat Liver
- Melting Granulation by Addition of Polyethyleneglycol for Stabilization of TAT-59
- Effects of Grinding and Tableting on Physicochemical Stability of an Anticancer Drug, TAT-59
- Formation of Water-Insoluble Gel in Dry-Coated Tablets for the Controlled Release of Theophylline
- Application of Gel Formation for Taste Masking
- ラットにおけるリチウムの消化管吸収の制御
- Salivary Excretion of 5-Fluorouracil (5-FU). III. : Non-linear Kinetics of Salivary Excretion of 5-FU Following Bolus Intravenous Administration in Rats
- Dose-Dependent Salivary Excretion Following Bolus Intravenous Administration of Lithium in Dog
- Salivary Excretion of 5-Fluorouracil. I. Fluctuation of the Saliva/Plasma Concentration Ratio and Salivary Clearance in Beagle Dogs Following Bolus Intravenous Administration
- Distribution of Thiourea following Intravenous and Oral Administration to Rats
- Studies on Production of Higher Functional Pharmaceutical Preparations by Using Various Additives. III. Application of Hollow Glass Beads for Intragastric Floating Granules
- Studies on the Development of Intragastric Floating and Sustained Release Preparation. I. Application of Calcium Silicate as a Floating Carrier
- The Effect of Sacrificing Method on the Tissue Concentration of Exogeneous Creatinine in Rats
- 薬物の体内分布決定要因の定量的評価
- Influence of Anesthetic Regimens on the Intestinal Absorption of 5-Fluorouracil in Rats
- Gastric Emptying-Limited Oral Absorption of α-Linolenic Acid Administered as a Milk Fat-Globule Membrane (MFGM) Emulsion in Rats
- Evaluation of Milk Fat-Globule Membrane (MFGM) Emulsion for Oral Administration : Absorption of α-Linolenic Acid in Rats and the Effect of Emulsion Droplet Size
- Inter-organ Relation between Salivary Gland and Kidney in Lithium Excretion. IV. Saturation of Inhibitory Effect of NaCl on Ductal Reabsorption of Li^+ in Beagle Dogs
- Inter-organ Relation between Salivary Gland and Kidney in Lithium Excretion. III. Enhanced Salivary and Systemic Clearance of Li^+ by Oral Administration of NaCl in Dogs
- Salivary Excretion of 5-Fluorouracil (5-FU). V. Effect of 5-FU Concentration in Perfusate on the Salivary Excretion of 5-FU in Perfused Rat Mandibular Gland
- Inter-Strain Differences of Exogeneous Creatinine Disposition in Rats and Mice
- Effect of Hypothermia on the Disposition of Thiourea in Mice
- Elimination of Creatinine Following Intravenous Administration
- Effect of Convulsions Induced by Pentylenetetrazole or Electricity on the Dispositions of Creatinine and Urea in Rats
- Influence of Urethane Anesthesia and Abdominal Surgery on Gastrointestinal Motility in Rats