Studies on the Development of Intragastric Floating and Sustained Release Preparation. I. Application of Calcium Silicate as a Floating Carrier
スポンサーリンク
概要
- 論文の詳細を見る
We prepared an intragastric floating preparation using porous calcium silicate (Florite^[○!R] RE, FLR) as a floating carrier, which has floating ability due to the air included in the pores when they are covered with a polymer, it also has a sustained drug release property. Floating granules were prepared by dropping a 5 or 10% (w/v) ethanol solution of hydroxypropylcellulose (HPC) and ethylcellulose (EC) in 4 different concentration ratios while the FLR was being agitated in a beaker. After the mixture was dried in vacuo and sieved, we regarded the granules obtained as primary coated granules (PCG). After drying, the ethanol solution of the polymer was dropped and dried in vacuo again, and sieving was carried out to obtain secondary coated granules (SCG). The floating property and surface and inner structures of PCG and SCG were studies. Further, we prepared PCG and SCG including diclofenac sodium (DS) (DS-PCG, DS-SCG) as a model drug, and the drug release profile from these granules was observed.The floating property of SCG was better than that of PCG. A longer floating time was observed with a higher polymer concentration and a lower HPC composition ratio. It was observed by a scanning electron microscope (SEM) and the pore size distribution that more pores of FLR in SCG were covered with polymer than those in PCG. DS-SCG showed a smaller release rate than DS-PCG. These results suggest that FLR is a useful floating carrier for the development of floating and sustained release preparations.
- 公益社団法人日本薬学会の論文
- 1996-07-15
著者
-
林 弥生
College Of Pharmacy Kinjo Gakuin University
-
Kanaya Y
Laboratory Of Medical & Pharmaceutical Technology School Of Pharmacy Tokyo University Of Pharmac
-
Kanaya Yoshio
Laboratory Of Medical And Pharmaceutical Technology School Of Pharmacy Tokyo University Of Pharmacy
-
Kanaya Yoshio
Tokyo University Of Pharmacy And Life Science
-
Kanaya Yoshio
Laboratory Of Medical & Pharmaceutical Technology School Of Pharmacy Tokyo University Of Pharmac
-
YUASA Hiroshi
Laboratory of Medical and Pharmaceutical Technology, School of Pharmacy, Tokyo University of Pharmac
-
TAKASHIMA Yuki
Laboratory of Medical and Pharmaceutical Technology, School of Pharmacy, Tokyo University of Pharmac
-
Yuasa H
Department Of Pharmaceutics And Drug Delivery School Of Pharmacy Tokyo University Of Pharmacy And Li
-
Takashima Y
Department Of Hematology/oncology Shizuoka Children's Hospital
-
Yuasa Hiroaki
名古屋市立大学 薬研究薬剤学
-
Yuasa Hiroshi
Laboratory Of Medical & Pharmaceutical Technology School Of Pharmacy Tokyo University Of Pharmac
関連論文
- 01P1-144 ラットにおける経口投与後のnifedipineの消化管吸収に及ぼすカゼイ菌の影響(薬物相互作用(基礎と臨床),医療薬学の扉は開かれた)
- 乳酸カルシウムならびにアルギン酸ナトリウムをコーティングした顆粒からの不溶性ゲル形成を応用した楽物放出制御^1
- ラット腸管におけるビオチン輸送担体の機能解析
- 微量粉体試料における圧縮性評価
- 溶融造粒法を用いた抗癌剤TAT-59錠の安定化におけるポリエチレングリコールの分子量の影響^1
- 顆粒の準静的, 動的圧縮で得た錠剤の性状と圧縮プロセス
- 流動層コーティングにおける凝集抑制に関する研究(第4報)陽イオン添加における粒子凝集抑制
- グミ製剤の保存安定性
- グミ製剤からのアセトアミノフェンの放出性
- ゼラチンを用いたグミ製剤の調製
- Studies on Dissolution Tests for Soft Gelatin Capsules by the Rotating Dialysis Cell (RDC) Method. VI. Preparation and Evaluation of Ibuprofen Soft Gelatin Capsule
- 光および BHT 共存下における錠剤の変色
- コンドロイチン硫酸ナトリウムを用いた溶媒置換法による難溶性薬物の溶解性の向上
- Studies on the Granulation Process of Granules for Tableting with a High Speed Mixer. II. Influence of Particle Size of Active Substance on Granulation
- Effects of Compression Pressure on Physical and Chemical Stability of Tablets Containing an Anticancer Drug TAT-59
- Studies on the Granulation Process of Granules for Tableting with a High Speed Mixer. I. Physical Properties of Granules for Tableting
- ゲル形成を応用したコーティング顆粒からのテオフィリンの放出制御
- Ca 拮抗剤アムロジピンの患者における Population Pharmacokinetics
- Functional Characterization of Human Aquaporin 9 as a Facilitative Glycerol Carrier
- Absorption and Metabolic Extraction of Diltiazem from the Perfused Rat Small Intestine
- Saturable Absorption of Glycerol in the Rat Intestine(Biopharmacy)
- Kinetic Characterization of Carrier-Mediated Transport Systems for D-Glucose and Taurocholate in the Everted Sacs of the Rat Colon
- Search for Carrier-Mediated Transport Systems in the Rat Colon
- Effect of Maleylated Bovine Serum Albumin on the Disposition of Fractionated Heparin in Rats
- Uptake of FH by Two Types of Scavenger-Like Receptors in Rat Liver Parenchymal Cells in Primary Culture
- Uptake of Fractionated Heparin by Two Types of Scavenger Receptors in Isolated Rat Kupffer Cells
- Scavenger Receptor-Mediated Uptake of Fractionated [^3H] Heparin in Rat Peritoneal Macrophages
- First-Pass Metabolism of 5-Fluorouracil in the Perfused Rat Small Intestine
- Kinetic Characterization of Binding and Internalization of Fractionated [^3H]Heparin in Rat Liver Parenchymal Cells in Primary Culture
- Dose-Dependent Gastrointestinal Absorption of 5-Fluorouracil in Rats in Vivo
- Macromolecule-Macromolecule Interaction in Drug Distribution. V. Effects of Plasma Proteins on Uptake of Fractionated [^3H]Heparin in Isolated Rat Kupffer Cells
- Molecular Weight Dependency in the Uptake of Fractionated [^3H]Heparin in Isolated Rat Kupffer Cells
- Uptake Mechanism of Fractionated [^3H]Heparin in Isolated Rat Kupffer Cells : Involvement of Scavenger Receptors
- Macromolecule-Macromolecule Interaction in Drug Distribution. IV. Molecular Weight Dependency in the Interaction of Fractionated [^3H] Heparin with Plasma Proteins
- INTER-ORGAN RELATION BETWEEN SALIVARY GLAND AND KIDNEY IN LITHIUM EXCRETION UNDER CONTINUOUS STIMULATION OF SALIVATION IN DOGS : EFFECTS OF ORAL ADMINISTRATION OF NaCl OR KCl AND I.V. ADMINISTRATION OF SEVERAL DIURETICS ON LITHIUM CLEARANCES
- Inter-organ Relation between Salivary Gland and Kidney in Lithium Excretion. II. Salivary, Renal and Systemic Clearances of Lithium under Continuous Stimulation of Salivation in Water Loaded Dogs
- Investigation on Interaction of Fractionated ^3H-Heparin with Plasma Proteins by Gel Filtration Chromatography
- INTER-ORGAN RELATION BETWEEN SALIVARY GLAND AND KIDNEY IN LITHIUM EXCRETION : EFFECTS OF CONTINUOUS STIMULATION OF SALIVATION ON LITHIUM CLEARANCES IN DOGS
- 粘膜付着性の放出制御型フィルムからのリドカインの放出
- ラット小腸におけるニフェジピンの初回通過代謝
- ラット小腸におけるグリセロールの担体輸送機構の解析
- ソフトカプセル用o/w乳剤タイプ新規基剤の開発 II 犬におけるビタミンK_2含有新規ソフトカプセル製剤の経口投与後の吸収特性
- ラットにおける5-フルオロウラシルの初回通過代謝 : 小腸と肝との相対的寄与
- 薬物の唾液中排泄(第48報)イヌにおけるトリメタジオンの唾液中排泄 - 最適唾液採取時間の検討 -
- ラットにおけるリチウムの腸管膜透過機構
- Effect of Glycerol-Related Compounds on Carrier-Mediated Glycerol Uptake in HCT-15 Human Colon Cancer Cell Line
- ラット小腸 in situ 一回灌流法による doxycycline の腸管吸収の解析
- アフリカツメガエル卵母細胞発現系における aquaporin 9 の glycerol 輸送機構の解析
- 薬物腸管吸収に及ぼすプロバイオティクスの影響を探る
- Carrier-Mediated Transport of Glycerol in the Perfused Rat Small Intestine(Biopharmacy)
- Glycerol Uptake in HCT-15 Human Colon Cancer Cell Line by Na^+-Dependent Carrier-Mediated Transport(Biopharmacy)
- Glycerol Absorption by Na^+-Dependent Carrier-Mediated Transport in the Closed Loop of the Rat Small Intestine(Biopharmacy)
- Functional Characterization of the Carrier-Mediated Transport System for Glycerol in Everted Sacs of the Rat Small Intestine(Biopharmacy)
- ラット肝実質細胞でのグリセロール担体輸送の解析
- ラット小腸刷子縁膜小胞におけるリボフラビンの担体輸送
- ラット腸管からのシクロスポリンのバイオアベイラビリティーの投与部位差
- 分画ヘパリンの取り込みに関与するスカベンジャー受容体の多様性
- 遊離ラット小腸上皮細胞におけるriboflavinの担体輸送の解析
- ラット小腸におけるnifedipineの初回通過代謝の評価
- ラット小腸でのglycerolの輸送担体に及ぼすアルコール型薬物の影響
- 分画 heparin の体内動態におよぼす修飾ウシ血清アルブミンの影響 : in vivo と in vitro の関係
- 患者におけるアムロジピン錠投与後の体内動態の母集団解析
- 唾液中排泄における変動要因の研究 : TDMと医薬品開発のために
- ラットにおけるリチウム唾液中排泄に関する検討 : 水分負荷及びナトリウム負荷の影響
- Qualitative and Quantitative Detection of Cytomegalovirus DNA in Sera by PCR as a Clinical Marker
- Studies on Development of Dosage Forms for Pediatric Use (V) Oral Mucosal Irritation Study of Gummi Drugs in Hamster Cheek Pouch
- Studies on Development of Dosage Form for Pediatric Use (No.4) Time Courses of Plasma Concentration of Acetaminophen after Oral Administration of Gummi Drug and Powder Preparation in Dogs
- Studies on the Granulation Process of Granules for Tableting with a High Speed Mixer. III. Analysis of the Compression Process
- Application of Calcium Silicate for Medicinal Preparation. I. Solid Preparation Adsorbing an Oily Medicine to Calcium Silicate
- Melting Granulation by Addition of Polyethyleneglycol for Stabilization of TAT-59
- Effects of Grinding and Tableting on Physicochemical Stability of an Anticancer Drug, TAT-59
- Formation of Water-Insoluble Gel in Dry-Coated Tablets for the Controlled Release of Theophylline
- Application of Gel Formation for Taste Masking
- 口腔粘膜への適用を目的にしたフィルム状製剤の開発
- Studies on Internal Structure of Tablets. VI. Stress Dispersion in Tablets by Excipients
- ラットにおけるリチウムの消化管吸収の制御
- Salivary Excretion of 5-Fluorouracil (5-FU). III. : Non-linear Kinetics of Salivary Excretion of 5-FU Following Bolus Intravenous Administration in Rats
- Dose-Dependent Salivary Excretion Following Bolus Intravenous Administration of Lithium in Dog
- Salivary Excretion of 5-Fluorouracil. I. Fluctuation of the Saliva/Plasma Concentration Ratio and Salivary Clearance in Beagle Dogs Following Bolus Intravenous Administration
- Application of the Solid Dispersion Method to the Controlled Release of Medicine. VIII. Medicine Release and Viscosity of the Hydrogel of a Water-Soluble Polymer in a Three-Component Solid Dispersion System
- Application of the Solid Dispersion Method to the Controlled Release of Medicine. VII. Release Mechanism of a Highly Water-Soluble Medicine from Solid Dispersion with Different Molecular Weights of Polymer
- Studies on Production of Higher Functional Pharmaceutical Preparations by Using Various Additives. III. Application of Hollow Glass Beads for Intragastric Floating Granules
- Studies on the Development of Intragastric Floating and Sustained Release Preparation. I. Application of Calcium Silicate as a Floating Carrier
- Inter-organ Relation between Salivary Gland and Kidney in Lithium Excretion. IV. Saturation of Inhibitory Effect of NaCl on Ductal Reabsorption of Li^+ in Beagle Dogs
- Inter-organ Relation between Salivary Gland and Kidney in Lithium Excretion. III. Enhanced Salivary and Systemic Clearance of Li^+ by Oral Administration of NaCl in Dogs
- Salivary Excretion of 5-Fluorouracil (5-FU). V. Effect of 5-FU Concentration in Perfusate on the Salivary Excretion of 5-FU in Perfused Rat Mandibular Gland
- 22B-15 ラットにおける 5-フルオロウラシルの生物学的利用率の変動性に関する検討
- Results for 79 patients with neuroblastoma detected through mass screening at 6 months of age in a single institute
- Neuroblastoma detected by mass screening : the Tumor Board's role in its treatment
- Application of Carbopol^ to Controlled Release Preparations. II. Controlled Release by Use of Carbopol^ as a Matrix Material, as a Coating Material, and as Both
- Identification and Functional Characterization of Rat Riboflavin Transporter 2
- Fractional Absorption of L-Carnitine after Oral Administration in Rats : Evaluation of Absorption Site and Dose Dependency
- Dose Dependency in the Gastrointestinal Absorption of Cefatrizine : Correlation between in Vivo and in Situ
- Emulsion Type New Vehicle for Soft Gelatin Capsule Available for Preclinical and Clinical Trials : Stabilization of New Vehicle Containing Vitamin K_2 with PEG 6000
- Emulsion Type New Vehicle for Soft Gelatin Capsule Available for Preclinical and Clinical Trials : Effects of PEG 6000 and PVP K30 on Physicochemical Stability of New Vehicle
- Emulsion Type New Vehicle Available for Preclinical and Clinical Trials : Stability of Characteristics of Particle Size Distribution of New Vehicle
- Development of Emulsion Type New Vehicle for Soft Gelatin Capsule. I. Selection of Surfactants for Development of New Vehicle and Its Physicochemical Properties
- Salivary Excretion of 5-Fluorouracil (5-FU). IV. Dependency of Saliva/Plasma Concentration Ratio and Salivary Clearance on Plasma Concentration of 5-FU during Constant-Rate Intravenous Infusion in Rats
- Inter-organ Relation between Salivary Gland and Kidney in Lithium Excretion. I. Effects of Continuous Stimulation of Salivation on Salivary, Renal and Systemic Clearances of Lithium in Dog
- Salivary Excretion of 5-Fluorouracil. II. Fluctuation of Saliva/Plasma Concentration Ratio and Salivary Clearance during a Constant Rate Intravenous Infusion in Beagle Dogs