Application of Calcium Silicate for Medicinal Preparation. I. Solid Preparation Adsorbing an Oily Medicine to Calcium Silicate
スポンサーリンク
概要
- 論文の詳細を見る
Calcium silicate (Florite^<[○!R]> RE, FLR), a fine porous powder, was recently approved as a medicinal additive. In this study we sought to make a solid preparation by adsorbing an oily medicine to FLR; tocopheryl nicotinate (TN) was used as the oily medicine.TN adsorbed to FLR powder (TN-PO) was prepared by adsorbing TN ethanol solution to FLR and granulating with hydroxypropylcellulose (HPC) in order to improve the flowability. The results were as follows.FLR showed an excellent liquid holding ability compared with other excipients, and this was attributed to the high capillarity of the pores. In the absorbing process, FLR particles were granulated with TN overflowing from the pores or adhering to the particle surface. The angle of repose was decreased with increasing TN content, which was attributed to the process of granulation, and the angle of repose of the granules with a binder (TN-GR) was below 40°at any TN content.These results show that FLR is an useful additive for the solid preparation of an oily medicine.
- 公益社団法人日本薬学会の論文
- 1994-11-15
著者
-
金谷 芳雄
東京薬科大学
-
湯淺 宏
Tokyo College Of Parmacy
-
金谷 芳雄
Tokyo College of Pharmacy
-
高島 由季
東京薬科大学薬学部製剤設計学教室
-
Kanaya Yoshio
Laboratory Of Medical & Pharmaceutical Technology School Of Pharmacy Tokyo University Of Pharmac
-
Kanaya Yoshio
Tokyo College Of Pharmacy
-
朝日 第輔
Tokyo College of Parmacy
-
高島 由季
Tokyo College of Parmacy
-
篠沢 一也
Takeshima Seiyaku Co., Ltd.,
-
篠沢 一也
Takeshima Seiyaku Co. Ltd.
-
高島 由季
東京薬科大学 薬学部 製剤設計学教室
関連論文
- 散剤予製機による分包精度と粉体物性との関連性
- Studies on Improvement of Pharmaceutical Preparations Prescribed in Hospitals. III. : Prevention of Fading by Use of Solid Dispersion System of Ointment Containing Methylrosaniline Chloride
- 乳酸カルシウムならびにアルギン酸ナトリウムをコーティングした顆粒からの不溶性ゲル形成を応用した楽物放出制御^1
- P-59 子宮腺筋症及び深部内膜症治療を目的としたダナゾール膣錠の製剤設計
- 微量粉体試料における圧縮性評価
- 溶融造粒法を用いた抗癌剤TAT-59錠の安定化におけるポリエチレングリコールの分子量の影響^1
- 顆粒の準静的, 動的圧縮で得た錠剤の性状と圧縮プロセス
- 流動層コーティングにおける凝集抑制に関する研究(第4報)陽イオン添加における粒子凝集抑制
- グミ製剤の保存安定性
- グミ製剤からのアセトアミノフェンの放出性
- ゼラチンを用いたグミ製剤の調製
- Studies on Dissolution Tests for Soft Gelatin Capsules by the Rotating Dialysis Cell (RDC) Method. VI. Preparation and Evaluation of Ibuprofen Soft Gelatin Capsule
- 光および BHT 共存下における錠剤の変色
- コンドロイチン硫酸ナトリウムを用いた溶媒置換法による難溶性薬物の溶解性の向上
- Studies on the Granulation Process of Granules for Tableting with a High Speed Mixer. II. Influence of Particle Size of Active Substance on Granulation
- Effects of Compression Pressure on Physical and Chemical Stability of Tablets Containing an Anticancer Drug TAT-59
- Studies on the Granulation Process of Granules for Tableting with a High Speed Mixer. I. Physical Properties of Granules for Tableting
- Studies on Whisker Growth in Solid Preparations. VI. Whisker Growth in Mixtures Composed of Aspirin and Porous Glass Powder
- Effects of Water Content on Physical and Chemical Stability of Tablets Containing an Anticancer Drug TAT-59
- Studies on Internal Structure of Tablets. II. Effect of the Critical Disintegrator Amount on the Internal Structure of Tablets(Pharmaceutical)
- Studies on Whisker Growth on the Tablet Surface. III. : Mechanism of Whisker Growth on Aspirin Tablet and Its Effect on the Mechanical Strength of the Tablet
- Studies on Anisotropy of Compressed Powders. III. Effects of Different Granulation Methods on Anisotropy, Pore Size and Crushing Strength of Tablets
- ゲル形成を応用したコーティング顆粒からのテオフィリンの放出制御
- 徐放性マイクロスフェア型注射剤の開発による siRNA 制がん剤の創薬
- 針無し注射器による皮内免疫後の免疫活性評価
- 核移行シグナルおよびエレクトロポレーションによるヒト樹状細胞への遺伝子導入
- 長期徐放性マイクロスフェアならびに細胞透過性ペプチド修飾ナノ粒子による遺伝子デリバリー
- 医薬品添加剤多孔性ケイ酸カルシウムを用いた固形製剤の高機能化に関する研究
- DNAワクチンによるがん免疫療法のための遺伝子デリバリー(E・医療薬科学)
- 新規4流体ノズルスプレードライ法による粉末吸入剤用粒子の調製
- 圧力スイング造粒法による粉末吸入剤用2成分複合顆粒の調製と肺内in vitro吸入特性の評価
- Maltosyl-β-cyclodextrin ならびに sulphobutylether-β-cyclodextrin による pranlukast hydrate の包接挙動の解析、消化管吸収性に及ぼす影響
- 酸処理ビール酵母細胞壁の新規結合剤への応用
- 粘膜付着性の放出制御型フィルムからのリドカインの放出
- Changes in Physical Characteristics of Ethylaminobenzoate Tablets during Storage
- 薬学教育用の教育映画・ビデオ・スライド等
- Clinical Trend DDS製剤とQOL--より有効に,より安全に,より優しく
- Application of the Solid Dispersion Method to Controlled Release of Medicine. I. Controlled Release of Water Soluble Medicine by Using Solid Dispersion
- Studies on Development of Dosage Forms for Pediatric Use (V) Oral Mucosal Irritation Study of Gummi Drugs in Hamster Cheek Pouch
- Studies on Development of Dosage Form for Pediatric Use (No.4) Time Courses of Plasma Concentration of Acetaminophen after Oral Administration of Gummi Drug and Powder Preparation in Dogs
- Studies on the Granulation Process of Granules for Tableting with a High Speed Mixer. III. Analysis of the Compression Process
- Application of Calcium Silicate for Medicinal Preparation. I. Solid Preparation Adsorbing an Oily Medicine to Calcium Silicate
- Melting Granulation by Addition of Polyethyleneglycol for Stabilization of TAT-59
- Effects of Grinding and Tableting on Physicochemical Stability of an Anticancer Drug, TAT-59
- Formation of Water-Insoluble Gel in Dry-Coated Tablets for the Controlled Release of Theophylline
- Application of Gel Formation for Taste Masking
- 口腔粘膜への適用を目的にしたフィルム状製剤の開発
- Studies on Internal Structure of Tablets. VI. Stress Dispersion in Tablets by Excipients
- Application of the Solid Dispersion Method to the Controlled Release of Medicine. VIII. Medicine Release and Viscosity of the Hydrogel of a Water-Soluble Polymer in a Three-Component Solid Dispersion System
- Application of the Solid Dispersion Method to the Controlled Release of Medicine. VII. Release Mechanism of a Highly Water-Soluble Medicine from Solid Dispersion with Different Molecular Weights of Polymer
- Studies on Production of Higher Functional Pharmaceutical Preparations by Using Various Additives. III. Application of Hollow Glass Beads for Intragastric Floating Granules
- Studies on the Development of Intragastric Floating and Sustained Release Preparation. I. Application of Calcium Silicate as a Floating Carrier
- Studies on Internal Structure of Tablets. III. : Manufacturing of Tablets Containing Microcapsules
- Applicaiotn of the Solid Dispersion Method to the Controlled Release of Medicine. VI. Release Mechanism of a Slightly Water Soluble Medicine and Interaction between Flurbiprofen and Hydroxypropyl Cellulose in Solid Dispersion
- Application of the Solid Dispersion Method to the Controlled Release of Medicine. V. Suppression Mechanism of the Medicine Release Rate in the Three-Component Solid Dispersion System
- Application of the Solid Dispersion Method to Controlled Release of Medicine. II. Sustained Release Tablet Using Solid Dispersion Granule and the Medicine Release Mechanism
- Application of the Solid Dispersion Method to the Controlled Release of Medicine. IV. Precise Control of the Release Rate of a Water Soluble Medicine by Using the Solid Dispersion Method Applying the Difference in the Molecular Weight of a Polymer
- Application of the Solid Dispersion Method to the Controlled Release of Medicine. III. Control of the Release Rate of Slightly Water Soluble Medicine from Solid Dispersion Granules
- 網膜へのドラッグデリバリーの現状と課題
- Non-Invasive Ophthalmic Liposomes for Nucleic Acid Delivery to Posterior Segment of Eye
- siRNAの経皮デリバリー研究