Studies on Internal Structure of Tablets. III. : Manufacturing of Tablets Containing Microcapsules
スポンサーリンク
概要
- 論文の詳細を見る
The aim of this study was to establish the best manufacturing conditions for preparation by the direct compresison method of tablets which contain microcapsules having a minimal destruction rate of the coating wall, show the same dissolution pattern as microcapsules, and have enough mechanical strength for practical use, ant to elucidate the internal structure of the tablets under the best manufacturing conditions. Degree of destruction of the microcapsule wall was evaluated by the dissolution rate of the medicine in the microcapsules. To learn the mechanical strength of tablets, the crushing strength and friability were measured; their internal structure was analyzed by the porosity and pore size distribution.The best manufacturing conditions for the tablets were thus determined, and it was clarified by analysis of the internal structure that these conditions are markedly affected by the flowability of prescribed powders and the packing state at compression.
- 公益社団法人日本薬学会の論文
- 1990-03-25
著者
-
湯淺 宏
Tokyo College Of Parmacy
-
金谷 芳雄
Tokyo College of Pharmacy
-
Kanaya Yoshio
Tokyo College Of Pharmacy
-
小俣 一起
Taisho Pharmaceutical Co., Ltd.,
-
小俣 一起
Taisho Pharmaceutical Co. Ltd.
関連論文
- 散剤予製機による分包精度と粉体物性との関連性
- Studies on Improvement of Pharmaceutical Preparations Prescribed in Hospitals. III. : Prevention of Fading by Use of Solid Dispersion System of Ointment Containing Methylrosaniline Chloride
- 乳酸カルシウムならびにアルギン酸ナトリウムをコーティングした顆粒からの不溶性ゲル形成を応用した楽物放出制御^1
- 微量粉体試料における圧縮性評価
- 溶融造粒法を用いた抗癌剤TAT-59錠の安定化におけるポリエチレングリコールの分子量の影響^1
- 顆粒の準静的, 動的圧縮で得た錠剤の性状と圧縮プロセス
- 流動層コーティングにおける凝集抑制に関する研究(第4報)陽イオン添加における粒子凝集抑制
- グミ製剤の保存安定性
- グミ製剤からのアセトアミノフェンの放出性
- ゼラチンを用いたグミ製剤の調製
- Studies on Dissolution Tests for Soft Gelatin Capsules by the Rotating Dialysis Cell (RDC) Method. VI. Preparation and Evaluation of Ibuprofen Soft Gelatin Capsule
- 光および BHT 共存下における錠剤の変色
- コンドロイチン硫酸ナトリウムを用いた溶媒置換法による難溶性薬物の溶解性の向上
- Studies on the Granulation Process of Granules for Tableting with a High Speed Mixer. II. Influence of Particle Size of Active Substance on Granulation
- Effects of Compression Pressure on Physical and Chemical Stability of Tablets Containing an Anticancer Drug TAT-59
- Studies on the Granulation Process of Granules for Tableting with a High Speed Mixer. I. Physical Properties of Granules for Tableting
- Studies on Whisker Growth in Solid Preparations. VI. Whisker Growth in Mixtures Composed of Aspirin and Porous Glass Powder
- Effects of Water Content on Physical and Chemical Stability of Tablets Containing an Anticancer Drug TAT-59
- Studies on Internal Structure of Tablets. II. Effect of the Critical Disintegrator Amount on the Internal Structure of Tablets(Pharmaceutical)
- Studies on Whisker Growth on the Tablet Surface. III. : Mechanism of Whisker Growth on Aspirin Tablet and Its Effect on the Mechanical Strength of the Tablet
- Studies on Anisotropy of Compressed Powders. III. Effects of Different Granulation Methods on Anisotropy, Pore Size and Crushing Strength of Tablets
- ゲル形成を応用したコーティング顆粒からのテオフィリンの放出制御
- 粘膜付着性の放出制御型フィルムからのリドカインの放出
- Changes in Physical Characteristics of Ethylaminobenzoate Tablets during Storage
- 薬学教育用の教育映画・ビデオ・スライド等
- Application of the Solid Dispersion Method to Controlled Release of Medicine. I. Controlled Release of Water Soluble Medicine by Using Solid Dispersion
- Studies on the Granulation Process of Granules for Tableting with a High Speed Mixer. III. Analysis of the Compression Process
- Application of Calcium Silicate for Medicinal Preparation. I. Solid Preparation Adsorbing an Oily Medicine to Calcium Silicate
- Melting Granulation by Addition of Polyethyleneglycol for Stabilization of TAT-59
- Effects of Grinding and Tableting on Physicochemical Stability of an Anticancer Drug, TAT-59
- 口腔粘膜への適用を目的にしたフィルム状製剤の開発
- Application of the Solid Dispersion Method to the Controlled Release of Medicine. VIII. Medicine Release and Viscosity of the Hydrogel of a Water-Soluble Polymer in a Three-Component Solid Dispersion System
- Application of the Solid Dispersion Method to the Controlled Release of Medicine. VII. Release Mechanism of a Highly Water-Soluble Medicine from Solid Dispersion with Different Molecular Weights of Polymer
- Studies on Internal Structure of Tablets. III. : Manufacturing of Tablets Containing Microcapsules
- Applicaiotn of the Solid Dispersion Method to the Controlled Release of Medicine. VI. Release Mechanism of a Slightly Water Soluble Medicine and Interaction between Flurbiprofen and Hydroxypropyl Cellulose in Solid Dispersion
- Application of the Solid Dispersion Method to the Controlled Release of Medicine. V. Suppression Mechanism of the Medicine Release Rate in the Three-Component Solid Dispersion System
- Application of the Solid Dispersion Method to Controlled Release of Medicine. II. Sustained Release Tablet Using Solid Dispersion Granule and the Medicine Release Mechanism
- Application of the Solid Dispersion Method to the Controlled Release of Medicine. IV. Precise Control of the Release Rate of a Water Soluble Medicine by Using the Solid Dispersion Method Applying the Difference in the Molecular Weight of a Polymer
- Application of the Solid Dispersion Method to the Controlled Release of Medicine. III. Control of the Release Rate of Slightly Water Soluble Medicine from Solid Dispersion Granules