Studies on Dissolution Tests for Soft Gelatin Capsules by the Rotating Dialysis Cell (RDC) Method. VI. Preparation and Evaluation of Ibuprofen Soft Gelatin Capsule
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概要
- 論文の詳細を見る
We prepared soft gelatin capsules (SC) containing ibuprofen (IB), a widely used phenylpropionic acid-derived antiphologistic-analgesic drug. To evaluate the SC, in vitro dissolution tests were performed both by the paddle (PD) method described in the Japanese Pharmacopoeia (JP XII) and by the rotating dialysis cell (RDC) method which we previously developed and evaluated for application. In vivo, the blood IB concentration was determined after administration to beagles. Higher bioavailability was observed after administration of the SC containing IB than after administration of the bulk IB powder. A higher correlation was observed between the in vitro dissolution behavior and in vivo results by the RDC method than by the PD method, suggesting the usefulness of the RDC method in the dissolution test of SC.
- 社団法人日本薬学会の論文
- 1995-08-15
著者
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高橋 雅人
Laboratory Of Medical & Pharmaceutical Technology School Of Pharmacy Tokyo University Of Pharmac
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湯浅 宏
東京薬科大学
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金谷 芳雄
東京薬科大学
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湯浅 宏
東京薬科大学 薬学部製剤設計学教室
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内山 充
National Institute of Hygienic Sciences
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湯浅 宏
Laboratory of Medical & Pharmaceutical Technology, School of Pharmacy, Tokyo University of Pharmacy
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金谷 芳雄
Laboratory of Medical & Pharmaceutical Technology, School of Pharmacy, Tokyo University of Pharmacy
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Kanaya Yoshio
Laboratory Of Medical & Pharmaceutical Technology School Of Pharmacy Tokyo University Of Pharmac
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Kanaya Yoshio
Tokyo College Of Pharmacy
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Uchiyama M
Happy World Inc. Tokyo Jpn
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Takahashi Masato
Laboratory Of Medical & Pharmaceutical Technology School Of Pharmacy Tokyo University Of Pharmac
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