Toxicity of Organic Mercury Compounds. III. Uptake and Retention of Mercury in Several Organs of Mice by Long Term Exposure of Alkoxyethylmercury Compounds
スポンサーリンク
概要
- 論文の詳細を見る
Uptake and accumulation of alkoxyethylmercury compounds in several organs of mice, in comparison with alkylmercury compounds, were studied. Diets containing various organic mercury compounds were continuously fed to mice, and organic mercury in the organs was extracted with dithizone-carbon tetrachloride and determined by gas chromatography. Histological studies in mice poisoned by methoxyethylmercury chloride showed a prominent damage of the kidney, and proliferation of glial cells and atrophy of nervous cells in the cerebrum. In all of the compounds administered, the organic mercury was found in the liver and kidney. The ratio of the mercury contents in blood to plasma was higher in ethylmercury chloride than in alkoxyethylmercury compounds. Ethylmercury chloride was highly incorpolated into the brain, while alkoxyethylmercury compounds were at much slower rates. The mercury contents in the brain at onset of the neural symptoms were much lower in methoxyethylmercury than in ethylmercury. In the brain after administration of alkoxyethylmercury compounds, it appeared to be present as an inorganic mercury for the most part, in contrast with significant amounts of the organic mercury in the case of the alkylmercury. It may be presumed that manifestation of the symptoms after exposure of organic mercury compounds is not merely related to mercury levels and not always in need of organic forms in the brain.
- 公益社団法人日本薬学会の論文
- 1975-08-25
著者
-
石倉 俊治
東京理科大学薬学部
-
内山 充
National Institute of Hygienic Sciences
-
与那覇 政憲
東京理科大学薬学部
-
石倉 俊治
Faculty of Pharmaceutical Sciences, Tokyo University of Science
-
Uchiyama M
Happy World Inc. Tokyo Jpn
関連論文
- Application of Synthetic Hydrated Aluminum Silicates as Orally Administered Absorbents of Ammonium Ion
- 水道水の衛生化学的研究 : 給水用塩化ビニル資材から溶出する塩化ビニルモノマーと遊離残留塩素との反応
- 水道水の衛生化学的研究モデル資材としての純銅, 純亜鉛, 純鉛および純鉄との接触時におこる残留塩素の消失と水中金属濃度との関係
- 水道水の衛生化学的研究 : モデル鉄材との接触過程でおこる残留塩素の消失および第一鉄の残留
- マウス肝ミクロソームのチトクローム P-450 に対する有機リン殺虫剤
- Studies on Dissolution Tests for Soft Gelatin Capsules by the Rotating Dialysis Cell (RDC) Method. VI. Preparation and Evaluation of Ibuprofen Soft Gelatin Capsule
- Relase Rates on Indomethacin from Commercial Witepsol Suppositories and the Bioavailabilities in Rabbits and Pigs
- 水銀の迅速定量分析法に関する研究
- CHARACTERIZATION OF CONTAMINANTS IN EMS-ASSOCIATED L-TRYPTOPHAN SAMPLES BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
- 3-ANILINO-L-ALANINE, STRUCTURAL DETERMINATION OF UV-5,A CONTAMINANT IN EMS-ASSOCIATED L-TRYPTOPHAN SAMPLES