Toxicity of Organic Mercury Compounds. III. Uptake and Retention of Mercury in Several Organs of Mice by Long Term Exposure of Alkoxyethylmercury Compounds

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Uptake and accumulation of alkoxyethylmercury compounds in several organs of mice, in comparison with alkylmercury compounds, were studied. Diets containing various organic mercury compounds were continuously fed to mice, and organic mercury in the organs was extracted with dithizone-carbon tetrachloride and determined by gas chromatography. Histological studies in mice poisoned by methoxyethylmercury chloride showed a prominent damage of the kidney, and proliferation of glial cells and atrophy of nervous cells in the cerebrum. In all of the compounds administered, the organic mercury was found in the liver and kidney. The ratio of the mercury contents in blood to plasma was higher in ethylmercury chloride than in alkoxyethylmercury compounds. Ethylmercury chloride was highly incorpolated into the brain, while alkoxyethylmercury compounds were at much slower rates. The mercury contents in the brain at onset of the neural symptoms were much lower in methoxyethylmercury than in ethylmercury. In the brain after administration of alkoxyethylmercury compounds, it appeared to be present as an inorganic mercury for the most part, in contrast with significant amounts of the organic mercury in the case of the alkylmercury. It may be presumed that manifestation of the symptoms after exposure of organic mercury compounds is not merely related to mercury levels and not always in need of organic forms in the brain.
公益社団法人日本薬学会の論文
1975-08-25

Toxicity of Organic Mercury Compounds. III. Uptake and Retention of Mercury in Several Organs of Mice by Long Term Exposure of Alkoxyethylmercury Compounds

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