有機水銀化合物の毒性(第1報) : 塩化メトキシエチル水銀による水俣病様症状の発現

概要

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Diet mixed with different organic mercury compounds was fed continuously to dd strain male mice and mercury content in organs was estimated photometrically by the dithizone method after wet digestion of samples with nitric and sulfuric acids. Significant difference was observed in growth curves of mice given MEMC in doses of 1250 and 2500μg Hg/day from that of the control, and specific neural symptoms were observed in almost all the animals. In the case of MEMC, mercury content in the organs was the highest in the liver, followed by the kidney, spleen, and brain, in the decreasing order. Accumulation of mercury in the liver increased with an increasing dose, but no variation in the amount of accumulated mercury was observed in the kidney. In the case of BMC, accumulation of mercury in the brain was higher than that of MEMC.
公益社団法人日本薬学会の論文
1971-02-28