Effect of Zymosan on Hepatic Drug Metabolism in Mice
スポンサーリンク
概要
- 論文の詳細を見る
Effect of zymosan, a typical reticuloendotherial stimulator, on hepatic drug-metabolizing enzymes was examined in mice. 1) When given in vivo, it depressed all the activities of aminopyrine N-demethylase, p-nitroanisole O-demethylase, and aniline hydroxylase. It was shown that the effect of zymosan on drug metabolism was exerted solely on microsomes and there was a marked decrease of cytochrome P-450 content in microsomes of zymosan-treated animals. 2) Aminopyrine N-demethylase activity was found to become minimum 24 hours after the administration of zymosan. On the other hand, phagocytic activity was enhanced at the same time when the maximum depression of the metabolism of aminopyrine was observed.
- 公益社団法人日本薬学会の論文
- 1976-01-25
著者
-
北条 博史
東北大学薬学部
-
鈴木 康男
Pharmaceutical Institute, Tohoku University
-
小西 洋子
Pharmaceutical Institute Tohoku University
-
内山 充
National Institute of Hygienic Sciences
-
内山 充
Division of Drugs, National Institute of Hygienic Sciences
-
鈴木 康男
Pharmaceutical Institute Tohoku University
-
内山 充
Division Of Drugs National Institute Of Hygienic Sciences
関連論文
- 有機燐剤の各種動物コリンエステラーゼに対する作用(I)
- Stimulatory Effect of Ecdysterone on RNA Synthesis in Mouse Liver
- Stimulatory Effect of Insect-Metamorphosing Steroids from Ferns on Protein Synthesis in Mouse Liver
- 昆虫変態物質の連続投与の高等動物におよぼす影響その1
- Stimulation of Protein Synthesis in Mouse Liver by Ecdysterone
- Stimulatory Effect of Insect-Metamorphosing Steroids from Achyranthes and Cyathula on Protein Synthesis in Mouse Liver
- Stimulation of Protein Synthesis in Mouse Liver by Insect-Moulting Steroids
- Quantitative Determination of Cadmium, Copper, Manganese, and Lead in Water by Combination of Coprecipitation with Zirconium Hydroxide and Flame Atomic Absorption Spectrometry
- Application of Synthetic Hydrated Aluminum Silicates as Orally Administered Absorbents of Ammonium Ion
- マウス肝ミクロソームのチトクローム P-450 に対する有機リン殺虫剤
- Effect of Fenitrothion on Hepatic Microsomal Components of Drug Metabolizing System in Mice
- Studies on Dissolution Tests for Soft Gelatin Capsules by the Rotating Dialysis Cell (RDC) Method. VI. Preparation and Evaluation of Ibuprofen Soft Gelatin Capsule
- Separation and Some Characterizations of NADPH-Enoyl CoA Reductase (s) from Candida albicans
- 大麻成分の理化学的試験
- EXTRA-WEAK CHEMILUMINESCENCE OF DRUGS. II. RELATIONSHIP BETWEEN THE STRUCTURE AND THE EXTRA-WEAK CHEMILUMINESCENCE OF ORGANIC COMPOUNDS
- Relase Rates on Indomethacin from Commercial Witepsol Suppositories and the Bioavailabilities in Rabbits and Pigs
- ATOMIC FORCE MICROSCOPY OF DIMYRISTOYLPHOSPHATIDYLCHOLINE MEMBRANES
- Interaction of Eosin-5-maleimide with Band 3 of Human Erythrocytes
- Mechanism of Hypotonic Hemolysis of Human Erythrocytes
- Participation of Band 3 Protein in Hypotonic Hemolysis of Human Erythrocytes
- Color Chenge of New Coccine in a Lysozyme-Alimezine-Trimetoquinol Syrup : Optical Spectroscopic and Kinetic Analyses
- Electron Spin Resonance Studies of Phosphatidylcholine Interacted with Cholesterol and with a Hopanoid in Liposomal Membrane
- Interaction of Pentoxifylline with Human Erythrocytes. III. Comparison of Fluidity Change of Erythrocyte Membrane Caused by S-Adenosyl-L-methionine with That by Pentoxifylline
- Interaction of Liposomes with Human Erythrocytes
- Interaction of Pentoxifylline with Human Erythrocytes. II. : Effects of Pentoxifylline on the Erythrocyte Membrane
- Interaction of Pentoxifylline with Human Erythrocytes. I. : Interaction of Xanthine Derivatives with Human Erythrocyte Ghosts
- Alteration of Immunolysis Reaction on Liposome Membrane by Various Cholesterol Analogues
- CHARACTERIZATION OF IMMUNILIPOSOME MEMBRANE : ESP SPECTROSCOPIC ANALYSIS OF THE EFFECT OF CHOLESTEROL DERIVATIVES IN MEMBRANE
- Highly Sensitive Immunoliposome Assay of Theophylline
- Optical Resolution of Drugs by Cyclodextrin Complexation
- Characteristics of Anion Transport Channels in the Human Erythrocyte. I. Interactions between Eosin 5-Isothiocyanate and Band 3 Proteins
- Biphasic Photolysis of Riboflavin. III. Effects of Ionic Strength on the Photolysis
- マススペクトロメトリーの裁判化学領域への応用(第2報)アヘンアルカロイドの定量
- 質量分析法によるバルビツール酸系催眠薬およびその体内代謝産物の確認
- 舌乳頭部位に存在するエステラーゼ類の研究(第3報) : エステラーゼ類の分類
- 舌乳頭部位に存在するエステラーゼ類の研究(第2報) : コリンエステラーゼ類の電気泳動による分離
- ガスクロマトグラフィーによる催眠薬の分析 : 裁判化学試験法の改良研究 I
- 農薬の残留毒性に関する研究(IV)
- 浸透殺虫剤の散布による温室内空気汚染について
- Effect of Bacteriohopane-32-ol on Lipid Metabolism in Hep G2 Cells
- CHARACTERIZATION OF CONTAMINANTS IN EMS-ASSOCIATED L-TRYPTOPHAN SAMPLES BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
- 3-ANILINO-L-ALANINE, STRUCTURAL DETERMINATION OF UV-5,A CONTAMINANT IN EMS-ASSOCIATED L-TRYPTOPHAN SAMPLES
- ^3H標識Mannanの生体内運命(第2報)組織中のMannanの免疫学的検討
- 酵母Mannanの前処理による抗腫瘍性効果
- FORMULATION-ASSISTED BIODEGRADABLE POLYMER MATRICES
- Application of Gel Permeation chromatograph-Low Angle Laser Light Scattering System to Kinetic Study on Degradation of Bioerodible Polymers
- The Kinetics of the Racemization of Oxazepam in Aqueous Solution
- Stability of Pilocarpine Ophthalmic Formulations
- Synthetic Hydrated Aluminum Silicates as Oral Adsorbents of Potassium Ion
- ベンゼン中におけるクロロタロニルの光分解
- An Improved Chemiluminescence-Based Liposome Immunoassay Involving Apoenzyme
- A Liposome Immunoassay Based on a Chemiluminescense Reaction
- Effect of Zymosan on Hepatic Drug Metabolism in Mice. II. Identification of Active Component of Yeast Cell Walls
- Effect of Zymosan on Hepatic Drug Metabolism in Mice
- Effect of Organophosphate Pesticide on Acid Cholesterol Esterase in Rat Liver
- Modified Lipophilic Vitamin. III. Distribution and Excretion of Tocopheronolactone
- Modified Lipophilic Vitamin. II. Effect of Tocopheronolactone on Lipid-Peroxidation
- ビタミンK類縁物質の脂質過酸化反応にたいする影響
- Tocopheronolactoneの生理活性について(第1報)
- Enzyme-Histochemical Studies on the Inhibitory Effect of Organophosphorus Pesticides on the Porcine Blood Cholinesterase
- Toxicity of Organic Mercury Compounds. IV. Metabolism and Excretion of Alkoxyethylmercury Compounds in Mice
- Toxicity of Organic Mercury Compounds. III. Uptake and Retention of Mercury in Several Organs of Mice by Long Term Exposure of Alkoxyethylmercury Compounds
- Spectrofluorometric Determination of FUT-175 (Nafamstat Mesilate) in Blood Based on Trypsin-Inhibitory Activity
- Effect of Inserted Bacteriohopane-32-ol on the Stability of Liposomal Membranes
- 有機リン剤被曝者の非散布時期におけるコリンエステラーゼ活性とグルタチオンの相関関係について
- Properties of Thiobarbituric Acid-reactive Materials obtained from Lipid Peroxide and Tissue Homogenate
- Effect of Pyrithioxine on Phospholipids Constituents of Tissue
- Effect of Pyrithioxine on the Histo-Hematic Barriers
- Effects of Trivalent and Hexavalent Chromium on Lipid Peroxidation in Rat Liver Microsomes
- Studies on the Anti-Tumor Activity of Polysaccharides. I. Isolation of Hemicelluloses from Yakushima-bamboo and Their Growth Inhibitory Activities against Sarcoma-180 Solid Tumor
- Biphasic Photolysis of Riboflavin. II. Effect of Gelatin on the Photolysis
- Distribution and Excretion of ^3H-Amantadine HCl
- Comparison of Inhibitory Actions of Organophosphate Pesticides on Cholinesterase and Lecithin-Cholesterol Acyltransferase in Human Plasma
- Drug Sensor : An Enzyme Immunoelectrode for Theophylline
- 日本薬学会学術賞受賞 橋本嘉幸氏の業績
- ^3H標識Mannanの生体内運命(第1報)
- 有機リン農薬阻害ヒト血球コリンエステラーゼに対するin Vitroにおけるグルタチオンの効果
- ホウレンソウホモジネイトによるパラチオンのニトロ基の還元について
- 4.薬学教育の中における公衆衛生(公衆衛生領域における薬学の使命)
- Photoreduction of Parathion by Spinach Chloroplasts. II. Ferredoxin-Independent Photoreduction of Parathion by Heated Chloroplasts with an Artificial Electron Donor System
- Photoreduction of Parathion by Spinach Chloroplasts
- The Release of β-Glucuronidase from Rat Liver by the Administration of Diazinon, the Organophosphorus Insecticide
- Inhibition of Enzyme Activities by 12-Keto Oleic Acid
- Acceleration of Lipid-Peroxidation by 12-Keto Oleic Acid
- Protection of Mammalia from the Poisoning of Radioactive Strontium. IV. Aluminum Citrate
- 有機リン系農薬の代謝と毒性
- 〔I〕シンポジウム"麻薬に関する諸問題 : 特にモルヒネを中心として"について(シンポジウム麻薬に関する諸問題 : 特にモルヒネを中心として : 第20回日本薬学大会)
- 〔I〕農薬の残留毒性の諸問題について(シンポジウム 農薬の残留毒性の諸問題 第19回日本薬学大会)
- 放射性ストロンチウムによる体内汚染の防禦に関する研究
- Studies on Chemical Analysis of Mycothoxin(Analysis of sterigmatocystin and 5-methoxysterigmatocystin using highperformance liquid chromatography with voltammetry detection)