Effect of Bacteriohopane-32-ol on Lipid Metabolism in Hep G2 Cells
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概要
- 論文の詳細を見る
To investigate the biological activity of the hopane group of pentacyclic triterpenes, the effect of bacteriohopane-32-ol (Monol) on lipid synthesis and secretion was determined using Hep G2 cells. Despite its structural similarity to 25-hydroxycholesterol, Monol did not affect free and esterified cholesterol synthesis determined by the incorporation from [^<14>C]acetate. Monol reduced the phospholipid secretion from Hep G2 cells without affecting cellular phospholipid synthesis from [^3H]glycerol. It also decreased the secretion of apolipoprotein B. These results suggest that the Monol-induced reduction in phospholipid secretion is due to a decrease in the number of lipoprotein particles secreted from Hep G2 cells.
- 社団法人日本薬学会の論文
- 1992-05-25
著者
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鈴木 康男
Pharmaceutical Institute, Tohoku University
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南雲 明
Central Research Laboratories Banyu Pharmaceutical Co. Ltd.
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鈴木 康男
Pharmaceutical Institute Tohoku University
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石田 史明
Central Research Laboratories, Banyu Pharmaceutical Co., Ltd.,
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亀井 敏夫
Central Research Laboratories, Banyu Pharmaceutical Co., Ltd.,
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鈴木 康男
Pharmaceutical Insitute Tohoku University
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