舌乳頭部位に存在するエステラーゼ類の研究(第3報) : エステラーゼ類の分類

概要

論文の詳細を見る
In a previous paper, a complex zymogram pattern of the esterases of the vallate papilla of rat tongue and foliate papilla of rabbit tongue was observed in homogenates containing Triton-X-100. The present work was carried out in order to classify these esterases according to their distinctive features in regard to the substrate specificity and its susceptibility to inhibitors. The ten esterases found in rat vallate papilla were classified into two cholinesterases, four arylesterases, three aliesterases, and one unidentified esterase. The unidentified esterase, which migrates towards the anodic side past the gel center, was characteristic of the rat vallate papilla, it was sensitive to eserine in high concentration, and insensitive to organophosphorus insecticides. These characters of the enzyme agree with the characteristics of the "eserine-sensitive noncholinesterase" which has been found in the nerve endings. Two cholinesterases, four arylesterases, and five aliesterases were separated from rabbit foliate papilla. The fact that the taste papilla was rich in cholinesterases and contained multiple forms of esterases suggests that these enzymes might have a certain role in the mechanisms of inducing the taste sensation.
社団法人日本薬学会の論文
1969-04-25