Interaction of Pentoxifylline with Human Erythrocytes. II. : Effects of Pentoxifylline on the Erythrocyte Membrane
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概要
- 論文の詳細を見る
The effects of pentoxifylline and other hemorheologically active drugs on the human erythrocyte membrane were examined by means of electron spin resonance spectroscopy. It was observed that the fluidity in the region of the phospholipid head groups in the erythrocyte bilayer was increased by an externally added drug. In this region, membrane fluidity was dependent on the incubation time, suggesting an interaction with membrane proteins. On the other hand, the acyl chain motion in the lower portion of the chain, the hydrophobic end, was reduced in the presence of the drugs. In this case, the acyl chain motion was not time-dependent. These changes of the membrane fluidity at different depths of the membrane induced by the drugs may correlate to the erythrocyte deformability.
- 社団法人日本薬学会の論文
- 1990-02-25
著者
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佐藤 幸夫
Faculty Of Pharmaceutical Sciences Tohoku University
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鈴木 康男
Pharmaceutical Institute, Tohoku University
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佐藤 幸夫
Pharmaceutical Institute, Tohoku University
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三浦 忠義
Sendai Teishin Hospital
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鈴木 康男
Pharmaceutical Institute Tohoku University
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佐藤 幸夫
東北大学薬学部
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Sato Yukio
Faculty Of Pharmaceutical Science Tohoku University
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鈴木 康男
Pharmaceutical Insitute Tohoku University
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