Effect of Fenitrothion on Hepatic Microsomal Components of Drug Metabolizing System in Mice

概要

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To examine the mechanisms of the inhibition of drug metabolizing enzyme activity by organophosphate insecticides, microsomal components of drug metabolizing system were determined after treatment with fenitrothion. Mice given intraperitoneal dose of fenitrothion exhibited the rapid decrease in cytochrome P-450 content and slight inhibition of NADPH-cytochrome c reductase activity. Administration of fenitrothion to phenobarbital-treated mice decreased in N-demethylation of aminopyrine as well as cytochrome P-450 content. The actual decrease in cytochrome P-450 content caused by fenitrothion in phenobarbital-treated mice was greater than non-treated mice. The results presented here strongly suggest that the inhibition of drug metabolizing enzyme by fenitrothion was due to the decrease in cytochrome P-450.
社団法人日本薬学会の論文
1975-09-25