Alteration of Immunolysis Reaction on Liposome Membrane by Various Cholesterol Analogues

概要

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Complement-mediated immunolysis was employed to examine the effect of incorporation of various cholesterol analogues, having a terminal hydroxyl group or terminal primary amine group at the 3-position of the cholestene nucleus, into the bilayer membrane of haptenated reverse-phase evaporation vesicles. An enhancement of immunolysis was observed when triethoxycholesterol(analogue II) was incorporated, while no measurable change was detected when the chain length of the substituted groups in hydroxy cholsterols was shorter than that of analogue II. However, for amino cholesterol analogues, a remarkabel decrease in immunolysis was seen. These results may arise from changes of membrane properties such as bilayer fluidity, lateral hapten mobility and complement fixation.
社団法人日本薬学会の論文
1988-10-25