Modified Lipophilic Vitamin. II. Effect of Tocopheronolactone on Lipid-Peroxidation

概要

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1) The effect of tocopheronolactone on two lipid-peroxidation systems, one is the enzymatic system coupled to NADPH oxidation and stimulated by ADP-Fe^<+2> mixture (NADPH-ADP-Fe^<+2> system), and the other is non-enzymatic system induced by ascorbate and Fe^<+2> (ascorbate-Fe^<+2> system), were studied. 2) The quinol form of tocopheronolactone inhibited the autoxidation of unsaturated fatty acid, but quinoid form of it, unlike ubiquinone and p-benzoquinone, did not show the antioxidant activity. 3) The enzymatic reduction of tocopheronolactone was inhibited by dicoumarol which peculiarly inhibit the quinone reductase. 4) Though antioxidant activity of tocopheronolactone on the ascorbate-Fe^<+2> lipidperoxidation system come into effect through the prior reduction to quinol, its activity on the NADPH-ADP-Fe^<+2> lipid-peroxidation system seems to be caused by intact quinone. Such assumption could be introduced by taking the effect of dicoumarol on above two system into consideration. 5) Tocopheronolactone did not inhibit the NADPH-linked metabolism of aminopyrine and codeine.
公益社団法人日本薬学会の論文
1969-09-25