Studies on the Metabolic N-Demethylation. III. Acceleration of Drug Metabolizing Enzyme in Rat Liver.
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概要
- 論文の詳細を見る
The demethylation activity for the N-methylbarbiturates was localized in the microsomal fraction and required NADPH and oxygen. This activity was increased markedly with pretreatment of some barbiturates but not with carcinogenic substances such as DAB, 3-MC and benzpyrene. The activity of the demethylation or hydroxylation of barbiturates was generally decreased by the pretreatment of carcinogenic substances. In accord with the increase of enzyme activity, in the time course of induction after the pretreatment of phenobarbital, two maximum peaks were appeared around 24〜40 hours and 60〜70 hours when cyclobarbital, methylbarbital, and 3-methyl-MAB were employed as the substrates. By the pretreatment of 3-MC the demethylation of 3-methyl-MAB was stimulated, but the demethylation of methylbarbital was not.
- 公益社団法人日本薬学会の論文
- 1963-12-25
著者
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奥井 誠一
東北大学医学部薬学科
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黒岩 幸雄
Pharmaceutical Institute Tohoku University School Of Medicine
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奥井 誠一
Pharmaceutical Institute Tohoku University School Of Medicine
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嶺岸 謙一郎
Pharmaceutical Institute, Tohoku University School of Medicine
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嶺岸 謙一郎
Pharmaceutical Institute Tohoku University School Of Medicine
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