Studies on Improvement of Pharmaceutical Preparations Prescribed in Hospitals. III. : Prevention of Fading by Use of Solid Dispersion System of Ointment Containing Methylrosaniline Chloride

概要

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Conventionally, an aqueous solution of methylrosaniline chloride kneaded with 10% zinc oxide ointment has been used for disinfection and drying of operative wounds in our hospital. However, this ointment undergoes remarkable fading with time, and this is assumed to indicate a loss of antibacterial activity. Therefore, an attempt was made to improved the pharmaceutical characteristics of the ointment. Since methylrosaniline chloride in solid form is known to show little or no fading, an aqueous solution of methylrosaniline chloride was adsorbed on microcrystalline cellulose, which was then dried. The powder obtained by grinding the dried substance was kneaded with a zinc oxide ointment. The resulting ointment was found to be an effective preparation, showing less fading and an extremely small loss of antibacterial activity.
社団法人日本薬学会の論文
1986-02-25