塩化リゾチーム軟膏(リフラップ^<[○!R]>軟膏)の配合変化

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Lysozyme chloride ointment (Reflap^<[○!R]> o.) has been widely used in clinical practice as a remedy for skin ulcers, and highly valued for its efficacy. Since skin ulcers, however, are liable to be complicated by infections and inflammations, Reflap^<[○!R]> o. is often coadministered with other kind of ointment at our institution depending on the conditions of lesions. In the light of this fact, we undertook a study to determine the effects of combination therapy with Reflap^<[○!R]> o. mixed with antibiotics, antimicrobials, disinfectants, steroid or non-steroid antiphlogistics ointments. In this study, Reflap^<[○!R]> o. was mixed with these ointments in a 1:1 ratio by weight. In order to determine compatibility, the mixtures were examined for (1) uniformity of kneading or changes in the properties of component ointments, (2) changes in color, (3) decrease in lysozyme chloride activity, and (4) reduction in potency or content of ointments added to Reflap^<[○!R]> o. As the result, it was found that Reflap^<[○!R]> o. was compatible with Gentacin^<[○!R]>, Panimycin^<[○!R]>, Rinderon^<[○!R]>-V, Eksalb^<[○!R]>, Kenacort^<[○!R]>-A, Anderm^<[○!R]>, Staderm^<[○!R]>, and Fenazol^<[○!R]> ointments. On the other hand, Reflap^<[○!R]> o. was incompatible with Achromycin^<[○!R]>, Terramycin^<[○!R]>, Baramycin^<[○!R]> ointments, Geben^<[○!R]>, Mafatate^<[○!R]> creams, and Isodine^<[○!R]> Gel.
日本医療薬学会の論文
1989-02-20

塩化リゾチーム軟膏(リフラップ^<[○!R]>軟膏)の配合変化

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