Studies on the Granulation Process of Granules for Tableting with a High Speed Mixer. III. Analysis of the Compression Process
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概要
- 論文の詳細を見る
Several kinds of theophylline granules were prepared in a high speed mixer by varying the kneading time, and their compression processes were analyzed by Heckel and by Cooper and Eaton equations. The compressibility of those granules was also examined comparatively by analyzing the compression energy applied to the powder layer to determine the relation between the compression behavior, compression energy, tablet hardness and internal structure of the tablet.The granules having the largest pore volumes were found to have high tablet hardness and tended to show larger ratios of compression loss energy to compression energy. It was suggested that in the granules having the largest pore volumes, the pores were easily filled by particle movement, rearrangement, plastic deformation and brittle fracture upon compression and the energy applied to the powder layer upon tableting was consumed efficiently.
- 公益社団法人日本薬学会の論文
- 1997-08-15
著者
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Kanaya Yoshio
Tokyo University Of Pharmacy And Life Science
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Kondo S
Nippon Hoechst Marion Roussel Ltd.
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Kanaya Yoshio
Tokyo College Of Pharmacy
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Kanaya Yoshio
Tokyo University Of Pharmacy
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SHIRAISHI Tatsuro
Nippon Hoechst Marion Roussel Ltd.,
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YAGUCHI Yoshikatsu
Nippon Hoechst Marion Roussel Ltd.,
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KONDO Shuji
Nippon Hoechst Marion Roussel Ltd.,
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YUASA Hiroshi
Tokyo University of Pharmacy
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Shiraishi Tatsuro
Nippon Hoechst Marion Roussel Ltd.
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Yaguchi Y
Nippon Hoechst Marion Roussel Ltd.
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