Studies on Development of Dosage Forms for Pediatric Use (V) Oral Mucosal Irritation Study of Gummi Drugs in Hamster Cheek Pouch
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概要
- 論文の詳細を見る
In the present study we investigated irritation of the oral mucosa and the safety of gummi drugs containing acetaminophen (AAP). The oral mucosae of hamsters were macroscopically examined for any evidence of irritation after gummi drugs were inserted into the cheek pouch and left there for 1h. The cheek pouch tissue was also macroscopically and microscopically examined 24h after gummi drugs were withdrawn from the cheek pouch.As a result, no evidence of irritation was found macroscopically 1h after insertion, or macroscopically and microscopically 24h after the withdrawal of the gummi drugs or placebos as compared with negative controls (saline). Considering these results, the gummi drugs administered in the present study produced no irritation to the oral mucosa.
- 公益社団法人日本薬学会の論文
- 1998-01-15
著者
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Kanaya Y
Laboratory Of Medical & Pharmaceutical Technology School Of Pharmacy Tokyo University Of Pharmac
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Kanaya Yoshio
Laboratory Of Medical And Pharmaceutical Technology School Of Pharmacy Tokyo University Of Pharmacy
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Kanaya Yoshio
Tokyo University Of Pharmacy And Life Science
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Kanaya Yoshio
Laboratory Of Medical & Pharmaceutical Technology School Of Pharmacy Tokyo University Of Pharmac
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NAMIKI Noriyuki
Department of Pharmacy, The Jikei University School of Medicine Daisan Hospital
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TAKAGI Nobuyuki
Department of Pharmacy, The Jikei University School of Medicine Daisan Hospital
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YUASA Hiroshi
Laboratory of Medical and Pharmaceutical Technology, School of Pharmacy, Tokyo University of Pharmac
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Namiki Noriyuki
Department Of Pharmacy The Jikei University School Of Medicine Daisan Hospital
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Namiki Noriyuki
Department Of Earth And Planetary Sciences Kyushu University
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Yuasa H
Laboratory Of Medical And Pharmaceutical Technology School Of Pharmacy Tokyo University Of Pharmacy
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Takagi N
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy And Life Sciences
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Takagi Nobuyuki
Department Of Electrical And Electronic Engineering Gifu University
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Yuasa Hiroshi
Laboratory Of Medical & Pharmaceutical Technology School Of Pharmacy Tokyo University Of Pharmac
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Takagi Nobuyuki
Department of Cardiovascular Surgery, Sapporo Medical University School of Medicine
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Namiki Noriyuki
Department of Clinical Pharmacology & Therapeutics, Hamamatsu University School of Medicine
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