Formulation Study for Orally Disintegrating Tablet Using Partly Pregelatinized Starch Binder
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概要
- 論文の詳細を見る
In this study, we aimed to design orally disintegrating tablets by employing a formulation design approach that enables the production of such tablets in the same facilities used for the production of solid dosage forms on an industrial scale. First, we examined the relationships between the types of binders used in the tablets and the properties of orally disintegrating tablets prepared by the wet granulation method. Results revealed that partly pregelatinized starch is a relatively suitable binder for orally disintegrating tablets as it also serves as a disintegrant. Next, we employed a central composite design for 2 factors, namely, corn starch and partly pregelatinized starch, in order to design granules suited for orally disintegrating tablets composed of D-mannitol, corn starch or partly pregelatinized starch. The effects of these 2 factors on 3 types of responses, namely, 50% granule size, compressing index and disintegrating index, were analyzed with a software package, and responses to changes in the factors were predicted. This study investigated the effects of binder type and binder content in orally disintegrating tablets, and provided evidence that the binder exerts a strong influence on tablet properties, and is therefore an important component of orally disintegrating tablets.
- 公益社団法人 日本薬学会の論文
著者
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Uchida Shinya
Department Of Biopharmacy School Of Pharmaceutical Sciences University Of Shizuoka
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Namiki Noriyuki
Department Of Earth And Planetary Sciences Kyushu University
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Kanada Ken
Pharmaceutical Laboratories Kissei Pharmaceuticalco. Ltd
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Yamada Masaki
Pharmaceutical Development Research Laboratory Tanabe Seiyaku Co. Ltd.
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Mimura Kazuki
Department of Pharmacy Practice and Science, School of Pharmaceutical Sciences, University of Shizuo
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Uchida Shinya
Department Of Anesthesiology Gunma University Hospital
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Uchida Shinya
Department of Pharmacy Practice and Science, School of Pharmaceutical Sciences, University of Shizuoka
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Mimura Kazuki
Department of Pharmacy Practice and Science, School of Pharmaceutical Sciences, University of Shizuoka
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Kanada Ken
Pharmaceutical Research & Development, Kissei Pharmaceutical Co., Ltd.
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Namiki Noriyuki
Department of Clinical Pharmacology & Therapeutics, Hamamatsu University School of Medicine
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