Anti-cancer Activities of Pyrazolo[1,5-a]indole Derivatives
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概要
- 論文の詳細を見る
The structure activity relationship (SAR) in the anti-cancer activities of pyrazolo[1,5-a]indole derivatives was investigated, and the following conclusions were obtained : 1) N(1)-quaternarization is essential for anti-cancer activity, 2) the size and polarity of the 2-substituent is crucial for in vitro activity which allows further investigation in an in vivo test, 3) the effect of the 4-substituent on the activity is minor compared with the other two factors.
- 公益社団法人日本薬学会の論文
- 2000-11-01
著者
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Katayama H
Niigata Coll. Pharmacy Niigata Jpn
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Katayama Hajime
Niigata College Of Pharmacy
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Kaneko Kimiyoshi
Niigata College of Pharmacy
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Kanada Ken
Pharmaceutical Laboratories Kissei Pharmaceuticalco. Ltd
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Kaneko K
Niigata College Of Pharmacy
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Katayama H
Niigata College Of Pharmacy
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KIRYU Yoshimitsu
Niigata College of Pharmacy
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OHSHIMA Rie
Niigata College of Pharmacy
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