Formation of Water-Insoluble Gel in Dry-Coated Tablets for the Controlled Release of Theophylline

スポンサーリンク

概要

• 論文の詳細を見る

• Sodium alginate (ALNa) of a natural polysaccharide is known to form a water-insoluble gel when combined with a bivalent metal. In this study, we prepared tablets containing ALNa and calcium gluconate (GLCa) as a bivalent metal, and studied the application of the water-insoluble gel involving the controlled release of a test drug by permeation of water. Dry-coated tablets containing theophylline (TP) as a model drug, ALNa and GLCa were prepared by the dry powder compression method.The controlled release of TP was evaluated by the dissolution test according to JP XIII. The release rate was extremely high for the tablets which contained only TP and GLCa. A zero order or sigmoidal release profile was observed for the tablets that contained only TP and ALNa. On the other hand, the lowest dissolution rate and a sigmodidal release profile were observed for the tablet containing TP and GLCa in its core and ALNa in its outer phase. These results suggest that dry-coated tablets containing ALNa and GLCa and prepared by the direct powder compression method would be useful for the controlled release of drugs.

• 公益社団法人日本薬学会の論文
• 1998-04-15

著者

• 齋藤 直樹

  Meiji Pharmaceutical University

• 林 弥生

  College Of Pharmacy Kinjo Gakuin University

• Kanaya Y

  Laboratory Of Medical & Pharmaceutical Technology School Of Pharmacy Tokyo University Of Pharmac

• Kanaya Yoshio

  Laboratory Of Medical And Pharmaceutical Technology School Of Pharmacy Tokyo University Of Pharmacy

• Kanaya Yoshio

  Tokyo University Of Pharmacy And Life Science

• Kanaya Yoshio

  Laboratory Of Medical & Pharmaceutical Technology School Of Pharmacy Tokyo University Of Pharmac

• YUASA Hiroshi

  Laboratory of Medical and Pharmaceutical Technology, School of Pharmacy, Tokyo University of Pharmac

• KANEKO Kaoru

  Pharmaceutical Laboratories, Kissei Pharmaceutical Co., Ltd.,

• KANADA Ken

  Pharmaceutical Laboratories, Kissei Pharmaceutical Co., Ltd.,

• MIYAGI Masaharu

  Pharmaceutical Laboratories, Kissei Pharmaceutical Co., Ltd.,

• SAITO Noriyasu

  Pharmaceutical Laboratories, Kissei Pharmaceutical Co., Ltd.,

• OZEKI Tetsuya

  Laboratory of Medical & Pharmaceutical Technology, School of Pharmacy, Tokyo University of Pharmacy

• Kanada Ken

  Pharmaceutical Laboratories Kissei Pharmaceuticalco. Ltd

• Kaneko K

  Niigata College Of Pharmacy

• Ozeki Tetsuya

  Department Of Pharmaceutics And Drug Delivery School Of Pharmacy Tokyo University Of Pharmacy And Li

• Yuasa H

  Department Of Pharmaceutics And Drug Delivery School Of Pharmacy Tokyo University Of Pharmacy And Li

• Saito Noriyasu

  Pharmaceutical Laboratories Kissei Pharmaceutical Co. Ltd.

• Yuasa Hiroaki

  名古屋市立大学 薬研究薬剤学

• Yuasa Hiroshi

  Laboratory Of Medical & Pharmaceutical Technology School Of Pharmacy Tokyo University Of Pharmac

• Miyagi M

  Kumamoto Inst. Technol. Kumamoto Jpn

• Miyagi Masaharu

  Pharmaceutical Laboratories Kissei Pharmaceutical Co. Ltd.

関連論文

• An Acylated Cyanidin 3,7-diglucoside in the Bluish Flowers of Bletilla striata
• Triacylated Anthocyanidin 3-Arabinosylglucoside-7,3’-diglucosides Isolated from the Bluish Flowers of Tradescantia virginiana Cultivars and Their Distribution in the Tradescantieae
• Acylated Cyanidin 3-sophoroside-5-glucosides from the Purple Roots of Red Radish (Raphanus sativus L.) ‘Benikanmi’
• Chemistry of Renieramycins. Part 4. Synthesis of a Simple Natural Marine Product, 6-Hydroxy-7-methoxyisoquinolinemethanol
• Synthetic Approaches toward Ecteinascidins. Part 2. Preparation of the ABCDE Ring System of Ecteinascidins Having Characteristic Substituents in Both Benzene Rings
• Chemistry of Antitumor Isoquinolinequinone Alkaloids: Unexpected Oxidative Degradation of Saframycin S to Generate Simple Isoquinoline Alkaloids, Mimosamycin and Mimocin (Heterocycles 30th in Anniversary Issue)
• 13C NMR Spectral Assignment of 5-Hydroxy-1,5-imino-3-benzazocin-4,7,10-trione Derivatives: The Revised Structure of Renieramycin H
• 114(P-44) 海洋生物由来新規サフラマイシン系天然物の構造と合成研究(ポスター発表の部)
• A Practical Synthesis of the ABC Ring Model of Ecteinascidins
• 生体内酸化還元反応に関与する含窒素キノンの役割
• 10 サフラマイシン系抗生物質の合成研究 : 光学活性サフラマイシンMx2の全合成(口頭発表の部)
• Synthesis of Saframycins. X. Transformation of (-)-Saframycin A to (-)-Saframycin Mx Type Compound with the Structure Proposed for Saframycin E
• Synthesis of Saframycins. VIII. Synthesis of the ABC Ring of Safracins
• SYNTHESIS OF SAFRAMYCINS. VI. THE USEFUL TRANSFORMATION OF (-)-SAFRAMYCIN A TO (-)-SAFRAMYCIN Mx TYPE COMPOUND
• ちょっとした工夫から有用な反応が見つかる : 最近のDiels-Alder反応を例にとって
• 62 サフラマイシン系抗生物質の合成研究 : サフラマイシンCおよびDの合成(ポスター発表の部)
• SYNTHESIS OF SAFRAMYCINS. IV. : SELENIUM OXIDE OXIDATION OF 4-OXO-HEXAHYDRO-1,5-IMINO-3-BENZAZOCIN-7,10-DIONE; PROMISING METHOD TO CONSTRUCT SAFRAMYCINS C AND D FROM SAFRAMYCIN B
• 中員環を有するセスタテルペノイドの全合成
• A Facile Synthesis of 1,2,3,4-Tetrahydroisoquinolines through Cyclization of O, N-Acetals. II. : Syntheses of Isoquinolinequinone Antibiotics
• Synthssis of Saframycins. II. : Preparations and Reactions of N-Methyl-2,5-piperazinediones
• Preparations and Reactions of (Z)-3-Arylidene-6-arylmethyl-2,5-piperazinediones Having Highly Oxygenated Benzene Rings(Organic,Chemical)
• STRUCTURE OF SAFRAMYCIN D, A NEW DIMERIC ISOQUINOLINEQUINONE ANTIBIOTIC(Communications to the Editor)
• 60 サフラマイシンBの全合成研究
• 01P1-144 ラットにおける経口投与後のnifedipineの消化管吸収に及ぼすカゼイ菌の影響(薬物相互作用(基礎と臨床),医療薬学の扉は開かれた)
• ラット腸管におけるビオチン輸送担体の機能解析
• Ca 拮抗剤アムロジピンの患者における Population Pharmacokinetics
• Functional Characterization of Human Aquaporin 9 as a Facilitative Glycerol Carrier
• Absorption and Metabolic Extraction of Diltiazem from the Perfused Rat Small Intestine
• Saturable Absorption of Glycerol in the Rat Intestine(Biopharmacy)
• Kinetic Characterization of Carrier-Mediated Transport Systems for D-Glucose and Taurocholate in the Everted Sacs of the Rat Colon
• Search for Carrier-Mediated Transport Systems in the Rat Colon
• Effect of Maleylated Bovine Serum Albumin on the Disposition of Fractionated Heparin in Rats
• Uptake of FH by Two Types of Scavenger-Like Receptors in Rat Liver Parenchymal Cells in Primary Culture
• Uptake of Fractionated Heparin by Two Types of Scavenger Receptors in Isolated Rat Kupffer Cells
• Scavenger Receptor-Mediated Uptake of Fractionated [^3H] Heparin in Rat Peritoneal Macrophages
• First-Pass Metabolism of 5-Fluorouracil in the Perfused Rat Small Intestine
• Kinetic Characterization of Binding and Internalization of Fractionated [^3H]Heparin in Rat Liver Parenchymal Cells in Primary Culture
• Dose-Dependent Gastrointestinal Absorption of 5-Fluorouracil in Rats in Vivo
• Macromolecule-Macromolecule Interaction in Drug Distribution. V. Effects of Plasma Proteins on Uptake of Fractionated [^3H]Heparin in Isolated Rat Kupffer Cells
• Molecular Weight Dependency in the Uptake of Fractionated [^3H]Heparin in Isolated Rat Kupffer Cells
• Uptake Mechanism of Fractionated [^3H]Heparin in Isolated Rat Kupffer Cells : Involvement of Scavenger Receptors
• Macromolecule-Macromolecule Interaction in Drug Distribution. IV. Molecular Weight Dependency in the Interaction of Fractionated [^3H] Heparin with Plasma Proteins
• INTER-ORGAN RELATION BETWEEN SALIVARY GLAND AND KIDNEY IN LITHIUM EXCRETION UNDER CONTINUOUS STIMULATION OF SALIVATION IN DOGS : EFFECTS OF ORAL ADMINISTRATION OF NaCl OR KCl AND I.V. ADMINISTRATION OF SEVERAL DIURETICS ON LITHIUM CLEARANCES
• Inter-organ Relation between Salivary Gland and Kidney in Lithium Excretion. II. Salivary, Renal and Systemic Clearances of Lithium under Continuous Stimulation of Salivation in Water Loaded Dogs
• Investigation on Interaction of Fractionated ^3H-Heparin with Plasma Proteins by Gel Filtration Chromatography
• INTER-ORGAN RELATION BETWEEN SALIVARY GLAND AND KIDNEY IN LITHIUM EXCRETION : EFFECTS OF CONTINUOUS STIMULATION OF SALIVATION ON LITHIUM CLEARANCES IN DOGS
• ラット小腸におけるニフェジピンの初回通過代謝
• ラット小腸におけるグリセロールの担体輸送機構の解析
• ソフトカプセル用o/w乳剤タイプ新規基剤の開発 II 犬におけるビタミンK_2含有新規ソフトカプセル製剤の経口投与後の吸収特性
• ラットにおける5-フルオロウラシルの初回通過代謝 : 小腸と肝との相対的寄与
• 薬物の唾液中排泄(第48報)イヌにおけるトリメタジオンの唾液中排泄 - 最適唾液採取時間の検討 -
• ラットにおけるリチウムの腸管膜透過機構
• Effect of Glycerol-Related Compounds on Carrier-Mediated Glycerol Uptake in HCT-15 Human Colon Cancer Cell Line
• ラット小腸 in situ 一回灌流法による doxycycline の腸管吸収の解析
• アフリカツメガエル卵母細胞発現系における aquaporin 9 の glycerol 輸送機構の解析
• 薬物腸管吸収に及ぼすプロバイオティクスの影響を探る
• Carrier-Mediated Transport of Glycerol in the Perfused Rat Small Intestine(Biopharmacy)
• Glycerol Uptake in HCT-15 Human Colon Cancer Cell Line by Na^+-Dependent Carrier-Mediated Transport(Biopharmacy)
• Glycerol Absorption by Na^+-Dependent Carrier-Mediated Transport in the Closed Loop of the Rat Small Intestine(Biopharmacy)
• Functional Characterization of the Carrier-Mediated Transport System for Glycerol in Everted Sacs of the Rat Small Intestine(Biopharmacy)
• ラット肝実質細胞でのグリセロール担体輸送の解析
• ラット小腸刷子縁膜小胞におけるリボフラビンの担体輸送
• ラット腸管からのシクロスポリンのバイオアベイラビリティーの投与部位差
• 分画ヘパリンの取り込みに関与するスカベンジャー受容体の多様性
• 遊離ラット小腸上皮細胞におけるriboflavinの担体輸送の解析
• ラット小腸におけるnifedipineの初回通過代謝の評価
• ラット小腸でのglycerolの輸送担体に及ぼすアルコール型薬物の影響
• 分画 heparin の体内動態におよぼす修飾ウシ血清アルブミンの影響 : in vivo と in vitro の関係
• 患者におけるアムロジピン錠投与後の体内動態の母集団解析
• 唾液中排泄における変動要因の研究 : TDMと医薬品開発のために
• ラットにおけるリチウム唾液中排泄に関する検討 : 水分負荷及びナトリウム負荷の影響
• Spontaneous Mutations of the Flavonoid 3'-hydroxylase Gene Conferring Reddish Flowers in the Three Morning Glory Species
• The Gene Encoding Flavanone 3-Hydroxylase is Expressed Normally in the Pale Yellow Flowers of the Japanese Morning Glory Carrying the speckled Mutation Which Produce Neither Flavonol nor Anthocyanin but Accumulate Chalcone, Aurone and Flavanone
• In Vitro Inhalation Behavior of Spherically Agglomerated Steroid Particles with Carrier Lactose.
• Diacylated 8-C-Glucosylcyanidin 3-Glucoside from the Flowers of Tricyrtis formosana
• Melting Granulation by Addition of Polyethyleneglycol for Stabilization of TAT-59
• Effects of Grinding and Tableting on Physicochemical Stability of an Anticancer Drug, TAT-59
• Formation of Water-Insoluble Gel in Dry-Coated Tablets for the Controlled Release of Theophylline
• Application of Gel Formation for Taste Masking
• An Acylated Pelargonidin 3-Sophoroside from the Pale-brownish Red Flowers of Ipomoea nii
• A Novel Acylated Pelargonidin 3-Sophoroside-5-glucoside from Greyish-Purple Flowers of the japanese Morning Glory
• Acylated Pelargonidin 3-Sophoroside-5-glucosides from the Flowers of the Japanese Morning Glory Cultivar 'Violet'
• ラットにおけるリチウムの消化管吸収の制御
• Salivary Excretion of 5-Fluorouracil (5-FU). III. : Non-linear Kinetics of Salivary Excretion of 5-FU Following Bolus Intravenous Administration in Rats
• Dose-Dependent Salivary Excretion Following Bolus Intravenous Administration of Lithium in Dog
• Salivary Excretion of 5-Fluorouracil. I. Fluctuation of the Saliva/Plasma Concentration Ratio and Salivary Clearance in Beagle Dogs Following Bolus Intravenous Administration
• Studies on Production of Higher Functional Pharmaceutical Preparations by Using Various Additives. III. Application of Hollow Glass Beads for Intragastric Floating Granules
• Studies on the Development of Intragastric Floating and Sustained Release Preparation. I. Application of Calcium Silicate as a Floating Carrier
• New diacylated delphinidin 3-rutinoside-5-glucosides isolated from the blue-purple flowers of Browallia speciosa
• Four acylated cyanidin 3-sambubioside-5-glucosides from the purple-violet flowers of lobularia maritima
• Genes Encoding the Vacuolar Na^+/H^+ Exchanger and Flower Coloration
• スタートライン : 薬学教育・新しい大学院博士前期(修士)課程
• Effect of Tranilast Oily Gel on Carrageenin-Induced Granulation in Rats
• Effect of UV-Absorbing Agents on Photodegradation of Tranilast in Oily Gels
• In Vitro Release of Tranilast from Oily Gels and Penetration of the Drug into Yucatan Micropig Skin
• Acylated Cyanidin 3,7,3'-Triglucosides with p-Hydroxybenzoic Acid from the Flowers of Dendrobium
• Application of Carbopol^ to Controlled Release Preparations. II. Controlled Release by Use of Carbopol^ as a Matrix Material, as a Coating Material, and as Both
• In vitro inhalation behavior of spherically agglomerated steroid particles with carrier lactose
• Flower Colors and their Anthocyanins in Matthiola incana Cultivars (Brassicaceae)
• FLORAL PIGMENTS ISOLATED FROM THE SKY-BLUE FLOWERS OF OXYPETALUM CAERULEUM

もっと見る 閉じる

スポンサーリンク